DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ces1e

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_598421.1	Gene:	Ces1e / 13897	MGIID:	95432	Length:	562	Species:	Mus musculus

Alignment Length:	558	Identity:	166/558 - (29%)
Similarity:	241/558 - (43%)	Gaps:	105/558 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPR---AKPMQKHFVLSI---------VEGSE 110
            |.|:|||:||:|.|||..|||..||..|::.| ||.   ..|:....|..:         ::.||
Mouse    51 FLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMCFQDPVTGQIVNDLLTNRKEKIPLQFSE 115

  Fly   111 DCLYLNVYSKR--LRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFM---QQDVVVVTFNYRVGA 170
            ||||||:|:..  .:||: |||:|||:|||...|  |...|  |..:   .::||||...||:|.
Mouse   116 DCLYLNIYTPADLTKSDR-LPVMVWIHGGGLVLG--GASTY--DGLVLSTHENVVVVVIQYRLGI 175

  Fly   171 LGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTR 235
            .||.|..|.  ...||.|..|||.||.|:..|||:|.|||.::|:.|||||..||..|:.:...:
Mouse   176 WGFFSTGDE--HSRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTIFGESAGGESVSVLVLSPLAK 238

  Fly   236 GLFHKAIMQSG-SMFCEWANEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITL- 298
            .||.:||.:|| ::......:.:...|.::|...|...:.:...|....||   :|....|.||
Mouse   239 NLFQRAISESGVALTAGLVKKNTRPLAEKIAVISGCKNTTSAAMVHCLRQK---TEEELLGTTLK 300

  Fly   299 -------VSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFE---- 352
                   :..:.|:.:   ||.|.|...:    :||:...|:|.|...|.:|.|:|.|..|
Mouse   301 LNLFKLDLHGDSRQSH---PFVPTVLDGV----LLPKMPEEILAEKNFNTVPYIVGINKQEFGWI 358

  Fly   353 --GLFSY------------QSTLHDEEHMLS----AFEVLIPREIREKSTQSHLKDLLRQFKVDN 399
              .:.:|            .|.|.....:|:    |..|.|.:.:|:|......||.|
Mouse   359 LPTMMNYPPSDVKLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLRDKDYTGRNKDQL------- 416

  Fly   400 FDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGK 464
                          |.::....|  |:...:::|.......|||:|.|.. ||.|:   ..|...
Mouse   417 --------------LELIGDVVF--GVPSVIVSRGHRDAGAPTYMYEFQY-SPSFS---SEMKPD 461

  Fly   465 HVRGVSHADDLSYLFYHILANKV---DKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEAL 526
            .|.| .|.|::    |.:....:   ..|..|....:.::..|..||||.|||..  |...|...
Mouse   462 TVVG-DHGDEI----YSVFGAPILRGGTSEEEINLSKMMMKFWANFARNGNPNGQ--GLPHWPEY 519

  Fly   527 DEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYDKNDL 564
            |:|  :..|.||...:.....:.|:...|..|..|..|
Mouse   520 DQK--EGYLQIGATTQQAQKLKEKEVAFWTELLAKKQL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	161/533 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	52/120 (43%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	162/547 (30%)
		Aes	44..>242	CDD:223730	83/197 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650