DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est1 and Ces1g

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	583	Identity:	162/583 - (27%)
Similarity:	238/583 - (40%)	Gaps:	120/583 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPM 97
            ||.|..|:|.|.........:....|.|:|||:||:|.|||..|:|..||..|:..| ||.....
Mouse    25 VVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQ 89

  Fly    98 QKHFVLSIVE------------GSEDCLYLNVYSKR-LRSDKPLPVIVWIYGGGFQFGEAGRDFY 149
            .....|.:.|            .||||||||:|:.. |..:..|||:|||:|||... :....:.
Mouse    90 NPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVI-DGASTYD 153

  Fly   150 SPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNIT 214
            .....:.::||||...||:|..||.|..|.  ...||.|..|||.||.|:..|||.|.|:|.::|
Mouse   154 GVPLAVHENVVVVVIQYRLGIWGFFSTEDE--HSRGNWGHLDQVAALHWVQDNIANFGGNPGSVT 216

  Fly   215 VMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMF--CEWANEPSGRWAYRLA--------CQLG 269
            :.|||||..||..|:.:...:.|||:||.||..:|  |.:     ||.|..||        |:..
Mouse   217 IFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLF-----GRAARPLAKKIAALAGCKTT 276

  Fly   270 YSGS-------ENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLP 327
            .|.:       :.|.|:.....|.....:...|      :.|..|   ||.|.|...:    :||
Mouse   277 TSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLG------DPRESY---PFLPTVIDGV----LLP 328

  Fly   328 RCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIP---------REIREKS 383
            :...|:|.|...|.:|.::|.|..|                  |..:||         |::.:|:
Mouse   329 KAPEEILAEKSFNTVPYMVGINKHE------------------FGWIIPMFLDFPLSERKLDQKT 375

  Fly   384 TQS---------HLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPA 439
            ..|         ::.:.|....::.:...|.......: |.:..:.....|:...:::|......
Mouse   376 AASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTD-LFLDLIGDIMFGVPSVIVSRSHRDAG 439

  Fly   440 TPTYLYRFDV-------DSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTI 497
            .|||:|.:..       |.|      |.:.|      .|||:| :..:.....|...|..|....
Mouse   440 APTYMYEYQYRPSFVSDDRP------QELLG------DHADEL-FSVWGAPFLKEGASEEEINLS 491

  Fly   498 QRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYD 560
            :.::..|..||||.|||..  |...|...|:|  :..|.||       :|....:|:.|:..|
Mouse   492 KMVMKFWANFARNGNPNGE--GLPHWPEYDQK--EGYLQIG-------VPAQAAHRLKDKEVD 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	158/562 (28%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	46/116 (40%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	162/583 (28%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	46/120 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832618
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650