DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and clt

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	195/550 - (35%)
Similarity:	294/550 - (53%)	Gaps:	49/550 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVR-DCTYPRAKPMQ 98
            |..:.|.:.| |::.|.:...|.:|.|:|:|:|||||||||:|:|...:.... ||:.......|
  Fly    22 VPVKQGVLVG-RQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQ 85

  Fly    99 KH-FVLSIVEGSEDCLYLNVYSKRLRSDK-PLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVV 161
            :. |.|. |.||||||:||||:.:::|.: ||||:|||:||||.||....||:.|...|:|:|:|
  Fly    86 RDPFTLE-VAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIV 149

  Fly   162 VTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVH 226
            ||.|||:||||||||.:.  .:.||.|||||.:||.|:.:|||.|||||.|:|:.|||||.:|||
  Fly   150 VTLNYRLGALGFLSLPEE--GIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVH 212

  Fly   227 ALMTTEQTRGLFHKAIMQSGSMFCEWA--NEPSGRWAYRLACQLG---YSGSENEKEVFRYLQKA 286
            ........:.||||||||||:...||.  ||...: ..|||..||   :.|.......|...:||
  Fly   213 LHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAK-TRRLAELLGGGDFGGDSKALLTFLQSEKA 276

  Fly   287 PASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREML--PEAWGNDLPLILGGN 349
            ..:.:.|..:.::|.:|||:::.|.|.||||...:.|..|.:...|::  .:..|: :|:|:|.|
  Fly   277 TPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGS-MPVIMGYN 340

  Fly   350 SFEGLFSYQSTLHDEEHMLSAFE----VLIPREI----REKSTQSHLKDLLRQFKVDNFDDATRG 406
            |.|||    :.:...:..|.|:|    .|:||.:    :....|....|:...|    |:.....
  Fly   341 SAEGL----AIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFF----FNGQALS 397

  Fly   407 RMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSH 471
            :...:..:.:.|..||...:.|.|....|....:|.|.||.|..... |.::::...:.:|||:|
  Fly   398 KENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGR-NLYKKIFQNEDLRGVAH 461

  Fly   472 ADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQM--- 533
            |||:.||| .:..::.:.:..:....:||..||..|||:..|:      ..|:.:  |.|..
  Fly   462 ADDICYLF-QMAGDETEMNRDDLMVTERLCEMWANFARDGKPS------PIWKPV--KKPHNGEP 517

  Fly   534 ----CLNIGKQLEFIVLPESKQNRIWDRLY 559
                ||.|.::|:....|:.::...|..:|
  Fly   518 IQLDCLLIDRELKMCSNPDGERMDFWRSMY 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	191/530 (36%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	64/116 (55%)
clt	NP_536784.1	COesterase	22..543	CDD:278561	193/544 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870