Protein Alignment alpha-Est1 and Nlgn2

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 597
• Identity: 169/597 - (28%)
• Similarity: 260/597 - (43%)
• Gaps: 118/597 - (19%)

  Fly    27 LGTKQTKVVCTRDGQVRGHRRRTLYDEEM--YFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC 89
            ||.::..||.|..|:|||.||. |.:|.:  ...|.|:|:|.||:|..||:.|:.|..|.|||:.
  Rat    36 LGEERFPVVNTAYGRVRGVRRE-LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNA 99

  Fly    90 -TYPRAKPMQKHFVLSIV------------------EGSEDCLYLNVY---------SKR----- 121
             |.|.|.|...|..|..:                  ..||||||||:|         .||
  Rat   100 TTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATL 164

  Fly   122 ------LRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRD 180
                  :|.....||:::::||.:..| .|..|.........:|:|.|.|||:|.|||||..|:
  Rat   165 NPPDTDIRDSGKKPVMLFLHGGSYMEG-TGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQ- 227

  Fly   181 LDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQS 245
             ...||.||.||:.||||:|:|||.|.|||:.||:.|..|||:.|:.|:.:..:.|||.|||.||
  Rat   228 -AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQS 291

  Fly   246 GSMFCEWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVL 309
            |:....|: |....::...||.::| ...|:..|....|::..:.|:..|.:     :..|.::
  Rat   292 GTAISSWSVNYQPLKYTRLLAAKVG-CDREDSTEAVECLRRKSSRELVDQDV-----QPARYHI- 349

  Fly   310 FPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHM-LSAFEV 373
             .|.|||:     ..|:|.....::.:....:..:::|.|..|||...:.:...|:.: .|||:.
  Rat   350 -AFGPVVD-----GDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDF 408

  Fly   374 LIPREIREKSTQSHLKDLLRQ---FKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLS 435
            .:...:.........||:||:   |...::.|...|.|. .:.|..|...|.|  :...|.....
  Rat   409 TVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMR-RKTLLALFTDHQW--VAPAVATAKL 470

  Fly   436 HAP-ATPTYLYRFDVDSPHFNHFRQVMCGKHVR----GVSHADDLSYLFYHILANKVD------- 488
            ||. .:|.|.|.|      ::|     |....|    ..:|.|:|.|:|...:....|
  Rat   471 HADYQSPVYFYTF------YHH-----CQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFS 524

  Fly   489 KSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNR 553
            |:.:....:  ::..|..||:..:||.|                    :.:..:||   .:|.||
  Rat   525 KNDVMLSAV--VMTYWTNFAKTGDPNQP--------------------VPQDTKFI---HTKPNR 564

  Fly   554 ----IWDRLYDK 561
                :|.:...|
  Rat   565 FEEVVWSKFNSK 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	161/570 (28%)
		Aes	<117..>233	CDD:223730	50/135 (37%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	167/591 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840