Protein Alignment alpha-Est1 and CES1

DIOPT Version :9

• Sequence 1: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 164/550 - (29%)
• Similarity: 243/550 - (44%)
• Gaps: 93/550 - (16%)

  Fly    59 FEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPM------------------QKHFVLS 104
            |.|||||:||:|.|||..|||..||..|::.| ||   ||                  :::..|.
Human    51 FLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYP---PMCTQDPKAGQLLSELFTNRKENIPLK 112

  Fly   105 IVEGSEDCLYLNVYSKR-LRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRV 168
            :   ||||||||:|:.. |.....|||:|||:|||...| |...:........::|||||..||:
Human   113 L---SEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVG-AASTYDGLALAAHENVVVVTIQYRL 173

  Fly   169 GALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQ 233
            |..||.|..|.  ...||.|..|||.||||:..|||.|.|:|.::|:.|||||..||..|:.:..
Human   174 GIWGFFSTGDE--HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPL 236

  Fly   234 TRGLFHKAIMQSG----SMFCEWAN-EP-SGRWAYRLACQLGYSG-------SENEKEVFRYLQK 285
            .:.|||:||.:||    |:..:..: :| :.:.|....|:...|.       .:.|:|:.....|
Human   237 AKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK 301

  Fly   286 APASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNS 350
            .....:..||....||            |::...|. ..:|.:...|:..|...:.:|.::|.|.
Human   302 MKFLSLDLQGDPRESQ------------PLLGTVID-GMLLLKTPEELQAERNFHTVPYMVGINK 353

  Fly   351 FE-------GLFSY---QSTLHDEEHMLSAFE----VLIPREIREKSTQSHLKDLLRQFKVDNFD 401
            .|       .|.||   :..|..:..|...::    |.|.:|:..::|:.:|         ...|
Human   354 QEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYL---------GGTD 409

  Fly   402 DATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHV 466
            |..:.:..|   |.:::...|  |:...::||.......|||:|.|.. .|.|:   ..|..|.|
Human   410 DTVKKKDLF---LDLIADVMF--GVPSVIVARNHRDAGAPTYMYEFQY-RPSFS---SDMKPKTV 465

  Fly   467 RGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIGPTTWEALDEKGP 531
            .| .|.|:|..:|..... |...|..|.:..:.::..|..||||.|||..  |...|...::|
Human   466 IG-DHGDELFSVFGAPFL-KEGASEEEIRLSKMVMKFWANFARNGNPNGE--GLPHWPEYNQK-- 524

  Fly   532 QMCLNIGKQLEFIVLPESKQNRIWDRLYDK 561
            :..|.||...:.....:.|:...|..|:.|
Human   525 EGYLQIGANTQAAQKLKDKEVAFWTNLFAK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	160/528 (30%)
		Aes	<117..>233	CDD:223730	50/116 (43%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	161/542 (30%)
		Aes	<122..>240	CDD:223730	50/120 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142665
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.700