DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and Ces1d

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	576	Identity:	171/576 - (29%)
Similarity:	240/576 - (41%)	Gaps:	97/576 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPM 97
            ||.|..|:|.|.........:....|.|:|||:||:|.|||..|||..||..|::.| ||   ||
Mouse    25 VVNTVKGKVLGKYVNLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYP---PM 86

  Fly    98 QKH-----FVLS----------IVEGSEDCLYLNVYSKR-LRSDKPLPVIVWIYGGGFQFGEAGR 146
            ...     .|||          .::.||||||||:|:.. |..:..|||:|||:|||...|.|.
Mouse    87 CSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGAS- 150

  Fly   147 DFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQ 211
            .:........::|||||..||:|..||.|..|.  ...||.|..|||.||||:..|||.|.|:|.
Mouse   151 TYDGLALSAHENVVVVTIQYRLGIWGFFSTGDE--HSRGNWGHLDQVAALRWVQDNIANFGGNPG 213

  Fly   212 NITVMGESAGAASVHALMTTEQTRGLFHKAIMQSG-----SMFCEWANEPSGRWAYRLACQLGYS 271
            ::|:.|||||..||..|:.:...:.|||:||.:||     ::........:|..|....|:...|
Mouse   214 SVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTS 278

  Fly   272 G-------SENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRDCVLPRC 329
            .       .:.|.|:.....|....::...|....|         :||.|.|...:    |||:.
Mouse   279 AVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKES---------YPFLPTVIDGV----VLPKA 330

  Fly   330 HREMLPEAWGNDLPLILGGNSFE------GLFSY------------QSTLHDEEHMLSAFEVLIP 376
            ..|:|.|...:.:|.|:|.|..|      .|..|            .|.|......|...|.:||
Mouse   331 PEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKISENMIP 395

  Fly   377 REIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATP 441
             .:.||             .:...||.|:.:..|.:.:     .....|:...:::|........
Mouse   396 -VVAEK-------------YLGGTDDLTKKKDLFQDLM-----ADVVFGVPSVIVSRSHRDAGAS 441

  Fly   442 TYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLV-GMWV 505
            ||:|.|:    :...|...|..|.|.| .|.|::..:|......  |.:|.|...:.::| ..|.
Mouse   442 TYMYEFE----YRPSFVSAMRPKAVIG-DHGDEIFSVFGSPFLK--DGASEEETNLSKMVMKFWA 499

  Fly   506 AFARNDNPNCPQIGPTTWEALDEKGPQMCLNIGKQLEFIVLPESKQNRIWDRLYDK 561
            .||||.|||..  |...|...|:|  :..|.||...:.....:.|:...|..|..|
Mouse   500 NFARNGNPNGG--GLPHWPEYDQK--EGYLKIGASTQAAQRLKDKEVSFWAELRAK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	167/554 (30%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	50/116 (43%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	168/568 (30%)
		Aes	<121..>239	CDD:223730	50/120 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650