DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and cel.2

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_001120027.1	Gene:	cel.2 / 100144991	XenbaseID:	XB-GENE-1217488	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	603	Identity:	170/603 - (28%)
Similarity:	250/603 - (41%)	Gaps:	119/603 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKMGTKLIGHKIVQYRLGTKQTKVVCTRDGQVRGHRRRT-LYDEEMYFAFEGIPFAQPPVGELRF 74
            |.|...::.|        .|...||.|..|.|.|..::. :...:....|:|||||.|
Frog     9 LAMACLVVAH--------AKTLGVVHTEGGFVEGTNKKIGVVFPDYIDIFKGIPFAAP------- 58

  Fly    75 RAPQP-----PHP-WLGVRDCTYPRAKPMQKHFVLSIVEGSEDCLYLNVYSKRLRS--DKPLPVI 131
              |:|     .|| |.|.......:.:.:|.......|.||.|||||||:..:.||  ...|||:
Frog    59 --PKPFEKAEKHPGWSGTLQAKDYKPRCLQATITQDNVFGSLDCLYLNVWVPQTRSQVSTNLPVM 121

  Fly   132 VWIYGGGFQFGEA-GRDFYS------PDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGL 189
            |||:||||..|.. |.:|.|      .:..|:..|:|||||||||.|||||..|.  :.|||.||
Frog   122 VWIFGGGFLLGSGQGANFLSNYLYDGEEVAMRGKVIVVTFNYRVGPLGFLSTGDS--NAPGNYGL 184

  Fly   190 KDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA- 253
            .||.||:.|:.:|||.|.|||.|||:.|||||.|||.....|....||..:||.|||...|.||
Frog   185 WDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLTPYNVGLIKRAISQSGVGLCPWAI 249

  Fly   254 -NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKA-PASEMAAQGITLVSQEERRQYVLFPFTPVV 316
             .:|. .||..||.:|| ....|.||:...|:.. |.:...|..:.|.:.|....:.| .::||:
Frog   250 QRDPL-TWAKSLASKLG-CPVNNTKELADCLRNTDPGALTIAYQLQLFNLEYPLVHYL-AYSPVI 311

  Fly   317 EPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSAFEVLIPREIRE 381
            :     ...:|...|.:...|.|.|  .|.|.|:.:|            |:.:..::....:...
Frog   312 D-----GDFIPDEPRNLFSNAAGVD--YIAGVNNMDG------------HLFAGVDLPAINQPLH 357

  Fly   382 KSTQSHLKDLLRQFKVDN--------FDDATRGRMEFNECLHILSVKHFW------HGIHRTVL- 431
            |.:...::.::|...:..        :|..|.|                |      ..:.|||:
Frog   358 KISTEQVQKVVRGLTLAKGVPALDIAYDLYTAG----------------WGTNPSQEDMKRTVVE 406

  Fly   432 ----------------ARLSHAPATPTYLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYLFY 480
                            ....:|....||.|.       |:|..::.......|..||:||.::|.
Frog   407 VETDYIFLVATQEALALHYQNAKGAKTYSYM-------FSHPSRMPVYPSWMGADHAEDLQFMFG 464

  Fly   481 HILANKVDKSSMEYQTIQRLVGMWVAFARNDNPNCPQIG-PTTWEALDEKGPQMCLNIGKQLEFI 544
            ...:..:.....:....|.::..|..||...:|:..:.. ||.|.|...:..|. |.|..::.:.
Frog   465 KPFSTPLAYRPRDRDVAQYMIAYWTNFAATGDPSKGESSIPTPWLAYSTENGQY-LEINHKINYQ 528

  Fly   545 VLPESKQN---RIWDRLY 559
            .:.:|.::   |.|.:.:
Frog   529 SMKQSLRSPYVRFWAQTF 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	164/563 (29%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	63/124 (51%)
cel.2	NP_001120027.1	COesterase	24..542	CDD:365897	165/574 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000