DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est1 and bchel

DIOPT Version :9

Sequence 1:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	XP_002937472.3	Gene:	bchel / 100135377	XenbaseID:	XB-GENE-5842192	Length:	559	Species:	Xenopus tropicalis

Alignment Length:	562	Identity:	162/562 - (28%)
Similarity:	249/562 - (44%)	Gaps:	103/562 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GHK-IVQYRLGTKQTKVVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHP 82
            ||: ||:.:.|......:..:.|.|.              |:.|||:.:||.|.|||:..:...|
Frog    29 GHENIVEVKQGKVSGINLSVKSGYVT--------------AYLGIPYGEPPTGRLRFKKTEQRKP 79

  Fly    83 WLGV-------RDCTYPRAK-----PMQKHFVLSIVEGSEDCLYLNVY---SKRLRSDKPLPVIV 132
            |.||       :.|...|..     |..:.|::: .|.|||||:|||:   ||    .|...|:|
Frog    80 WHGVLKADKFGKSCFQNRENKFAEFPGTEMFLVN-NEMSEDCLHLNVWVPPSK----PKDAHVMV 139

  Fly   133 WIYGGGFQFGEAGRDFYSPDYF-MQQDVVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMAL 196
            :|:||||:.|....|.|..... ..::|:||:.||||||.|||:|.... |.||||||.||.:||
Frog   140 FIHGGGFESGTTSLDIYDGSVLAYAENVIVVSMNYRVGAFGFLALPGHK-DAPGNAGLFDQRLAL 203

  Fly   197 RWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFCEWA---NEPSG 258
            :||::|||.|.|:|..:|:.|.|||||||...:.:.::...:::||:||||....||   .|.:.
Frog   204 QWINENIAAFGGNPDRVTIFGHSAGAASVGFHLISPKSYPYYNRAIVQSGSGTSNWALNSEERAK 268

  Fly   259 RWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYITRD 323
            |.|.:||..|....::::..:...|.:.|......|   |:::|   .|.|..|.|:|:.....|
Frog   269 RLALKLAEVLECPQTDDDAIITCLLNEDPKHLTEKQ---LLAKE---PYALTQFLPIVDHDFLVD 327

  Fly   324 CVLPRCHREMLPE-AWGNDL---PLILG-----GNSFEGLFSYQSTLHDEEHMLSAFEVLIPREI 379
                      :|| ..|..:   .::||     ||.|..:.|....:..|..:.||       |:
Frog   328 ----------VPENVLGQSMKRTDILLGITKDDGNPFTLIGSTDFNIQTESSISSA-------EL 375

  Fly   380 REK-------STQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHA 437
            .|:       :....::.:|.|:|  :::|...|  |.|.....|.::.::........||.:..
Frog   376 LERLKRFFPSAGDLGIQSILLQYK--DWEDVNNG--EKNRQAMELILRDYYFACPVKGFARYAVE 436

  Fly   438 PATPTYLYRFDVDS-----PHFNHFRQVMCGKHVRGVSHADDLSYLFYHILANKVDKSSMEYQTI 497
            .....:.|.:|..|     |.:            .|..|..:|..||.....||...:..|....
Frog   437 HQNNVFFYEYDHRSSNDPWPEW------------MGALHGAELPMLFGKPFINKGRYTRSELLFS 489

  Fly   498 QRLVGMWVAFARNDNPNCPQIGPTTW---EALDEKGPQMCLN 536
            :|::.:|..|||..:||........|   ...|||...:.||
Frog   490 KRIMKLWANFARTGSPNVEAEDGFVWPQYSLKDEKYAVLKLN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	158/552 (29%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	55/119 (46%)
bchel	XP_002937472.3	COesterase	31..547	CDD:395084	160/560 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910