DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Ache

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	178/609 - (29%)
Similarity:	286/609 - (46%)	Gaps:	119/609 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRF 74
            |:..||:..|.:..|        :::..:.||:||::.|.  ...|..||.|||:|:||||..||
  Rat    24 LLGGGARAEGREDPQ--------LLVRVRGGQLRGIRLKA--PGGPVSAFLGIPFAEPPVGSRRF 78

  Fly    75 RAPQPPEPWQGVLNCTTNRSKPMQR-NMLLGIVEG----------SEDCLHLNVYVKALKSEKPL 128
            ..|:|..||.|:|:.||.::...|. :.|....||          |||||:|||:....:...|.
  Rat    79 MPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPT 143

  Fly   129 PVIVWIYGGGFQKGEASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQ 192
            ||::|||||||..|.:|.|:|...:..: :..|.|::|||:...|||:|...: |.|||.||.||
  Rat   144 PVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSR-DAPGNVGLLDQ 207

  Fly   193 VMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPD 257
            .:||:|:.:|||.|.|||.::||.|||||:|||.:.:.:..:|.|||:|::|||        :|:
  Rat   208 RLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSG--------TPN 264

  Fly   258 NNW-----------AFRLAQNLGYK---GDEKDADVLSFLSKVCARQIAAIDQDVINLD----EV 304
            ..|           |..||:.:|..   ....|.:::|     |.|...|  ||:::.:    ..
  Rat   265 GPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIS-----CLRTRPA--QDLVDHEWHVLPQ 322

  Fly   305 RSFLLFAFGPVIEPYETDHCVVPKRHKDLLS---EAWGN-----DIPVIVGGNSFEGLFSYQLVR 361
            .|...|:|.||::             .|.||   ||..|     |:.|:||....||  ||.||.
  Rat   323 ESIFRFSFVPVVD-------------GDFLSDTPEALINTGDFQDLQVLVGVVKDEG--SYFLVY 372

  Fly   362 KDPWALKNFHNILPRE---------VRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALN--I 415
            ..|...|:..:::.|.         |.:.|.|..:.:::.....|:    .::...:.:|::  :
  Rat   373 GVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLH----PEDPAHLRDAMSAVV 433

  Fly   416 FSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDS-----PHFNQFRRLVCGDRIRGVAHADELS 475
            ..|..:.....   ||.:..|.....|.|.|:..:     |.:            .||.|..|:.
  Rat   434 GDHNVVCPVAQ---LAGRLAAQGARVYAYIFEHRASTLTWPLW------------MGVPHGYEIE 483

  Fly   476 YLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCP-ELGSAKWEAVQLKENAVEKCFNIS 539
            ::|...:...|:.:..|....:|::..||:||.:|:||.| :..|.:|...   ..|.::..:::
  Rat   484 FIFGLPLDPSLNYTVEERIFAQRLMKYWTNFARTGDPNDPRDSKSPRWPPY---TTAAQQYVSLN 545

  Fly   540 -HDLEMRDLPESDCLAVWDTFYPR 562
             ..||:|....:...|.|:.|.|:
  Rat   546 LKPLEVRRGLRAQTCAFWNRFLPK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	164/545 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	47/104 (45%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	171/588 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810