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Protein Alignment alpha-Est2 and TG

DIOPT Version :10

Sequence 1:	NP_524268.3	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	575	Identity:	129/575 - (22%)
Similarity:	224/575 - (38%)	Gaps:	160/575 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KMGAQLVGHK--VQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRF 74
            |.|..|:.::  |....:|| |..:|    |:.:.:|..|.:.:...|.  |:|||.||:.:.||
Human  2186 KPGISLLSYEASVPSVPIST-HGRLL----GRSQAIQVGTSWKQVDQFL--GVPYAAPPLAERRF 2243

  Fly    75 RAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEG-SEDCLHLNVYVKALKSEKPLPVIVWIYGGG 138
            :||:|.. |.|..:.:..|:...|.........| |||||:|||::.  ::..|...::..:...
Human  2244 QAPEPLN-WTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIP--QNVAPNASVLVFFHNT 2305

  Fly   139 FQKGEASRDIYSPDYFMKK--PVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQ 201
            ..:.|:.........|:..  .::.|..:||:...||||  ....:|.||.||.|||.||.|:..
Human  2306 MDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLS--SGSGEVSGNWGLLDQVAALTWVQT 2368

  Fly   202 NIAHFNGDPNNITLMGESAGS--ASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRL 264
            :|..|.|||..::|..:..|:  ||:|::........||.:|::..|.|||.
Human  2369 HIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSP------------- 2420

  Fly   265 AQNLGYKGDEKDADVLSFLSKVCARQIA---AIDQDVIN---------LDEVRSFLLFA------ 311
            |..:.::..::.|..|       |::::   :..|:|::         |::.::.||..
Human  2421 AAVISHERAQQQAIAL-------AKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHY 2478

  Fly   312 FGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPR 376
            :||||:    .|.:.....:.|....| .::.:::|.:..:||.:...      |:|.|.....|
Human  2479 WGPVID----GHFLREPPARALKRSLW-VEVDLLIGSSQDDGLINRAK------AVKQFEESRGR 2532

  Fly   377 EVRET-------SSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQS 434
            ...:|       :||.|:|                 |....||
Human  2533 TSSKTAFYQALQNSLGGED-----------------SDARVEA---------------------- 2558

  Fly   435 YAPKTPTYLYRFDFDSPHFNQFRR----------LVC---------GDRIRG---VAHADE---- 473
                ..|:.|..:..:..:..|.|          ::|         ..|.||   :.||.|
Human  2559 ----AATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGH 2619

  Fly   474 ------------LSYLFYNIIASKLDKSSMEYKTIE-RMVGMWTSFASSGNPNCP 515
                        |...||.....:.   |:|.|::. :::..::.|..|||||.|
Human  2620 GSLELLADVQFALGLPFYPAYEGQF---SLEEKSLSLKIMQYFSHFIRSGNPNYP 2671

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.