DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Ces2j

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	170/573 - (29%)
Similarity:	257/573 - (44%)	Gaps:	106/573 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQ 98
            |.:|..|||||........|.....|.|||:||||||.|||..|:.||||.||.:.|:..:..:|
  Rat    53 IRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQ 117

  Fly    99 RNM--LLGIVEG-------SEDCLHLNVYVKA-LKSEKPLPVIVWIYGGGFQKGEASRDIYSPDY 153
            ..|  |.|:.|.       |||||:||:||.| ...:..|||:|||:|||...|.||.:..| ..
  Rat   118 TAMMNLEGMKETELTKLPMSEDCLYLNIYVPAHAHEDSNLPVMVWIHGGGLVGGSASMNDAS-TL 181

  Fly   154 FMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGE 218
            ...:.:|.|:|.|||..|||.|..|.  ...||.|..||:.||||:.||||:|.|:.:::|:.|.
  Rat   182 AATEEIVIVSIQYRLGVLGFFSTGDQ--HARGNWGYLDQMAALRWVQQNIAYFGGNRDSVTIFGV 244

  Fly   219 SAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNL-GYKGDEKDADVLSF 282
            |||..||...:.:..::||||:||||||.||...:.|..:...::...|| |.:..:.:|.:.
  Rat   245 SAGGTSVSSHVVSPMSKGLFHRAIMQSGVALLPGLISDTSEVVYKTVANLSGCEASDSEALIR-- 307

  Fly   283 LSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVG 347
                |.|  |...|:::.:::|...:         |...|...:||..::||:....:.:|.|:|
  Rat   308 ----CLR--AKSKQEILAINQVFKMI---------PGVVDGKFLPKHPQELLASKDFHPVPSIIG 357

  Fly   348 GNSFE---------GLFSY--QLVRKD-PWALK--NFHNILPRE----VRETSSLEGQDLLVRRL 394
            .|:.|         ||:..  .:.|:. |.|||  ....:||.|    :.|....:.:|   ...
  Rat   358 VNTDECGWGVPTILGLYHIINNITRETLPAALKIAAAQMMLPPECIDLIMEEYMGDTED---AET 419

  Fly   395 KQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRL 459
            .|..|...:.:.:.:..||.: :|.|               ..:.|.|.|.|.    |...|.:
  Rat   420 LQAQFKEMLGDFIFVIPALQV-AHFQ---------------RSQAPVYFYEFQ----HLLSFIK- 463

  Fly   460 VCGDRIR----GVAHADELSYLFYNII-ASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGS 519
                ::|    ...|.|:..::|.:.. ....|.:..|.....|::..|.:||.:||||..:|
  Rat   464 ----QVRPFYPKADHGDDTVFVFGSYFWGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDL-- 522

  Fly   520 AKWEAVQLKENAVEKCFNISHD---LEMRDLP------ESDCLAVWDTFYPRE 563
            ..|..             :.||   |::...|      ::..|..|....|::
  Rat   523 PHWPV-------------LDHDEQYLQLNSQPAVGRALKARRLQFWTKTLPQK 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	162/522 (31%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/104 (43%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	168/564 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640