DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	177/559 - (31%)
Similarity:	253/559 - (45%)	Gaps:	100/559 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WPKLIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGD 71
            |...:..|..|:...||... |...:.|.:|..|||||........|.....|.|||:||||||.
  Rat     9 WLNAVFFGLLLLLIHVQGQH-SPESSPIRNTHIGQVRGKLDHVKDTKAGVHTFLGIPFAKPPVGP 72

  Fly    72 LRFRAPQPPEPWQGVLNCTTNRSKPMQ----------RNMLLGI--VEGSEDCLHLNVYVKALKS 124
            |||..|:.||||.||.:.|:..:..:|          :.|.|.:  |..|||||:||:|..|...
  Rat    73 LRFAPPEAPEPWSGVRDGTSQPAMCLQNLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAH 137

  Fly   125 E-KPLPVIVWIYGGGFQKGEASRDIYSPDYF-MKKPVVFVAINYRLAALGFLSLKDPKLDVPGNA 187
            | ..|||:|||:|||...|.||  :|..... :.:.:|.|.|.|||..|||.|..|.  ...||.
  Rat   138 EGSNLPVMVWIHGGGLMTGMAS--MYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDE--HARGNW 198

  Fly   188 GLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEW 252
            |..|||.||||:.||||||.|:|:.:|:.|||||...|...:.:..::||||.|||:||.||..:
  Rat   199 GYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPY 263

  Fly   253 -VESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVI 316
             :......::..:|:..|.:..:.:|.|      .|.|  |..:.:::.:::|...:
  Rat   264 LIADTSEMFSTMVAKVSGCEAMDSEALV------HCLR--AKSEAEILAINKVVQMV-------- 312

  Fly   317 EPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPRE---- 377
             |...|...:|:..|:||:......:|.|:|.|:.|..::..||......:|.    |.||
  Rat   313 -PAVVDGEFLPRHPKELLASEDFRPVPSIIGVNNDEYGWTIPLVMGTTQMIKE----LSRENLQA 372

  Fly   378 -VRETSS-----LEGQDLLVR---------RLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHR 427
             :::|::     ||..|||:.         :..|..|...|::.|.:..||.: :|.|..|
  Rat   373 ILKKTTAQLMLPLECSDLLMEEYMGDIEDPKTLQAQFTELMEDFMFVIPALQV-AHFQCSH---- 432

  Fly   428 FILARQSYAPKTPTYLYRF--------DFDSPHFNQFRRLVCGDRIRGVAHADELSYLF-YNIIA 483
                       .|.|.|.|        |...||       |..|      |.||:.::| |....
  Rat   433 -----------APVYFYEFQHQITFLKDIRPPH-------VKAD------HGDEIPFVFGYFFWD 473

  Fly   484 SKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKW 522
            .|.|.:..|.....||:..|.:||..||||..  |.:.|
  Rat   474 MKTDFTEEEKLLSRRMMKYWANFARHGNPNSE--GLSYW 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	171/534 (32%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	49/105 (47%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	171/536 (32%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	50/106 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640