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Protein Alignment alpha-Est2 and BCHE

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens

Alignment Length:	600	Identity:	174/600 - (28%)
Similarity:	266/600 - (44%)	Gaps:	130/600 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSTGHT---VILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN 88
            :...||   :|:.||.|:|||: ..||:. ....||.|||||:||:|.|||:.||....|..:.|
Human    23 IGKSHTEDDIIIATKNGKVRGM-NLTVFG-GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWN 85

  Fly    89 CTTNRSKPMQR-----------NMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKG 142
            .|...:...|.           .|.....:.|||||:|||::.|.| .|...|::||||||||.|
Human    86 ATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPK-PKNATVLIWIYGGGFQTG 149

  Fly   143 EASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLK-DPKLDVPGNAGLKDQVMALRWISQNIAH 205
            .:|..:|...:..: :.|:.|::|||:.|||||:|. :|  :.|||.||.||.:||:|:.:|||.
Human   150 TSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP--EAPGNMGLFDQQLALQWVQKNIAA 212

  Fly   206 FNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVES---PDNNWAFRLAQN 267
            |.|:|.::||.|||||:|||.:.:.:..:..||.:||:|||...:.|..:   ...|....||:.
Human   213 FGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKL 277

  Fly   268 LGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSF-------LLFAFGPVIE-PYETDHC 324
            .|. ..|.:.:::.     |.|.   .|...|.|:|  :|       |...|||.:: .:.||
Human   278 TGC-SRENETEIIK-----CLRN---KDPQEILLNE--AFVVPYGTPLSVNFGPTVDGDFLTD-- 329

  Fly   325 VVPKRHKDLLSE-AWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQD 388
             :|    |:|.| .......::||.|..||  :..||...|...|:.::|:.|:
Human   330 -MP----DILLELGQFKKTQILVGVNKDEG--TAFLVYGAPGFSKDNNSIITRK----------- 376

  Fly   389 LLVRRLKQLYFNNEMQESMEM-------FEALNIFSHRQIWHDTHR----------------FIL 430
                         |.||.:::       |...:|..|...|.|..|                ||.
Human   377 -------------EFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFIC 428

  Fly   431 ARQSYAPK-----TPTYLYRFDFDS-----PHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASK 485
            ....:..|     ...:.|.|:..|     |.:            .||.|..|:.::| .:...:
Human   429 PALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEW------------MGVMHGYEIEFVF-GLPLER 480

  Fly   486 LDKSSMEYKTIER-MVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLE--MRDL 547
            .|..:...:.:.| :|..|.:||..||||..:..|..|...:..|   :|...::.:..  |..|
Human   481 RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTE---QKYLTLNTESTRIMTKL 542

  Fly   548 PESDCLAVWDTFYPR 562
            ....| ..|.:|:|:
Human   543 RAQQC-RFWTSFFPK 556

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.