DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and NLGN2

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	615	Identity:	182/615 - (29%)
Similarity:	275/615 - (44%)	Gaps:	138/615 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT---- 91
            :::|.||:|||::|:  .:.|   |...|.|:|||.||:|..||:.|:.|..|.||.|.||
Human    43 VVNTAYGRVRGVRRE--LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPA 105

  Fly    92 ---NRSKPMQRNML------------LGIVEGSEDCLHLNVYVKALKSEKPL------------- 128
               |....:...||            ..:...|||||:||:||..  .:.||
Human   106 CPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPT--EDGPLTKKRDEATLNPPD 168

  Fly   129 ---------PVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVA-INYRLAALGFLSLKDPKLDV 183
                     ||:::::||.:.:|  :.:::..........|.|| :||||..|||||..|..  .
Human   169 TDIRDPGKKPVMLFLHGGSYMEG--TGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQA--A 229

  Fly   184 PGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCA 248
            .||.||.||:.||||:|:|||||.|||..||:.|..||::.|::::.:..:.|||.|||.|||.|
Human   230 KGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTA 294

  Fly   249 LSEW-VESPDNNWAFRLAQNLGYKGDEKD-ADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFA 311
            :|.| |......:...||..:|.  |.:| |:.:..|.:..:|::  :||||   ...|..:  |
Human   295 ISSWSVNYQPLKYTRLLAAKVGC--DREDSAEAVECLRRKPSREL--VDQDV---QPARYHI--A 350

  Fly   312 FGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGL-FSYQLVRKD--------PWAL 367
            ||||:     |..|||...:.|:.:....:..:::|.|..||| |.......:        .:.:
Human   351 FGPVV-----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTV 410

  Fly   368 KNFHNIL---PREVRETSSLEGQDLLVRRLKQLYF------NNEMQESMEMFEALNIFSHRQIWH 423
            .||.:.|   |         ||:|:|...:|.:|.      |.||:..    ..|.:|:..| |
Human   411 SNFVDNLYGYP---------EGKDVLRETIKFMYTDWADRDNGEMRRK----TLLALFTDHQ-W- 460

  Fly   424 DTHRFILARQSYAPKTPTYLYRFDFDSP-HFNQFRRLVCGDRIR----GVAHADELSYLF----- 478
                       .||...|.....|:.|| :|..|.. .|....|    ..||.|||.|:|
Human   461 -----------VAPAVATAKLHADYQSPVYFYTFYH-HCQAEGRPEWADAAHGDELPYVFGVPMV 513

  Fly   479 --YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKW---------EAVQLKENAV 532
              .::......|:.:....:  ::..||:||.:|:||.|.....|:         |.|..|.|:.
Human   514 GATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSK 576

  Fly   533 EKCF-NISHDLEMRDLPESDCLAVWDTFYP 561
            ||.: :|.....:||...::.:|.|....|
Human   577 EKQYLHIGLKPRVRDNYRANKVAFWLELVP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	170/574 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	44/126 (35%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	180/608 (30%)
		Aes	<170..>268	CDD:223730	41/101 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740