DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and cel.2

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	496	Identity:	148/496 - (29%)
Similarity:	221/496 - (44%)	Gaps:	84/496 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALK 123
            |:|||:|.||.   |.:.|.|...|:|||..|....:.:|.|:|.....||||||:||::|...|
Zfish    49 FKGIPFAAPPG---RLQKPVPHPGWEGVLKATEYSKRCIQLNLLQTDTMGSEDCLYLNIWVPQGK 110

  Fly   124 S-EKPLPVIVWIYGGGFQKGEASRDIYSPDYFM-------KKPVVFVAINYRLAALGFLSLKDPK 180
            : ...|||:|:||||||..|......:..:|..       :..|:.|..|||:.::||||..|
Zfish   111 TVSYNLPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGNVIVVTFNYRVGSMGFLSTGD-- 173

  Fly   181 LDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQS 245
            .|.|||.||.||..|:.|:.:||..|.|:|:|||:.||||||.||:..:.:.:.:||..:||.||
Zfish   174 ADAPGNYGLWDQHAAISWVHRNIKAFGGNPDNITIFGESAGSTSVNFQIISPKNKGLIRRAISQS 238

  Fly   246 GCALSEW-VESPDNNWAFRLAQNLGYKGD--------EKDADVLSFLSKVCARQIAAIDQDVINL 301
            |.||..| :......:|..:|:.:|...|        ..|...::...|| ....:|.:..|.||
Zfish   239 GVALCPWAINRNPRKFAEEIAKKVGCPTDSGMVACLRRTDPKAVTLAGKV-RLATSATEPIVHNL 302

  Fly   302 DEVRSFLLFAFGPVIE----PYETDHCVVPKRHKDLLSEAWGN--DIPVIVGGNSFEGLFSYQLV 360
                     ...|||:    |.|.|             ..:||  ||..|.|.|..:|.....|
Zfish   303 ---------YLSPVIDGDFIPDEPD-------------TLFGNAADIDYIAGVNDMDGHIFATL- 344

  Fly   361 RKDPWALKNFHNILPREVRE--------TSSLEGQDLLVRRLKQLYFN-------NEMQESMEMF 410
                 .:.:.:|.|.....|        .|...|||..:...::...|       .::::::...
Zfish   345 -----DIPSINNALATTTEEEVQALATALSKDRGQDAGIATFQEYTVNWGSKPNKEDIKKTVVEM 404

  Fly   411 EALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELS 475
            |...||   .:...|..::.:..:.:.:|.:||         |::..|:.......|..|||||.
Zfish   405 ETDYIF---LVPTQTALYLHSDNAKSARTYSYL---------FSESSRIPIFPLWMGADHADELQ 457

  Fly   476 YLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPE 516
            |:|.....:.|..........:.|:..||:||.:||||..|
Zfish   458 YVFGKPFTTPLGYFPRHRDVSKYMIAYWTNFAQTGNPNTGE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	148/496 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/111 (41%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	148/496 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.640