Protein Alignment alpha-Est2 and NLGN3

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 175/631 - (27%)
• Similarity: 266/631 - (42%)
• Gaps: 170/631 - (26%)

  Fly    35 LDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN-------C 89
            ::|.:|::||  .:.....|   |...:.|:|||.||:|:.||..|:||..|.|:.|       |
Human    44 VNTHFGKLRG--ARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVC 106

  Fly    90 TTNRSKPMQRNML-------LGIV-----EGSEDCLHLNVY-----VKALKSE---KP------- 127
            ..|....:...||       |.||     |.:||||:||||     ||.:..|   ||
Human   107 PQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRK 171

  Fly   128 ----------------------------LPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAI 164
                                        .||:|:|:||.:.:|..:. |..........|:.:.:
Human   172 GGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM-IDGSILASYGNVIVITL 235

  Fly   165 NYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMM 229
            |||:..|||||..|..  ..||.||.||:.||||:|:|||.|.|||..||:.|...|::.|.::.
Human   236 NYRVGVLGFLSTGDQA--AKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLT 298

  Fly   230 TTEQTRGLFHKAIMQSGCALSEW-VESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKV-CARQIA 292
            .:..:.|||.:||:|||.|||.| |......:...||..:|       .:||..:..| |.||.:
Human   299 LSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVG-------CNVLDTVDMVDCLRQKS 356

  Fly   293 A---IDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGL 354
            |   ::||:   ...|..:  ||||||     |..|:|...:.|:.:....:..:::|.|..|||
Human   357 AKELVEQDI---QPARYHV--AFGPVI-----DGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGL 411

  Fly   355 -FSYQLVRKDP----------WALKNFHNIL---PREVRETSSLEGQDLLVRRLKQLYFNNEMQE 405
             |...:|  ||          :::.||.:.|   |         ||:|.|...:|.:|.:...::
Human   412 KFVEGVV--DPEDGVSGTDFDYSVSNFVDNLYGYP---------EGKDTLRETIKFMYTDWADRD 465

  Fly   406 SMEMFE--ALNIFSHRQ------IWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCG 462
            :.|...  .:.:|:..|      :..|.|    ||..    :|||.|.|   ..|.....:....
Human   466 NPETRRKTLVALFTDHQWVEPSVVTADLH----ARYG----SPTYFYAF---YHHCQSLMKPAWS 519

  Fly   463 DRIRGVAHADELSYLF-------YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSA 520
            |    .||.||:.|:|       .::......|:.:....:  ::..||:||.:|:||.|.....
Human   520 D----AAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNKPVPQDT 578

  Fly   521 KWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYPRESLF 566
            |:  :..|.|..|:                   ..|..:.||:.|:
Human   579 KF--IHTKANRFEE-------------------VAWSKYNPRDQLY 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	168/586 (29%)
		Aes	<117..>221	CDD:223730	46/146 (32%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	175/631 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740