DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Ces2h

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	160/505 - (31%)
Similarity:	238/505 - (47%)	Gaps:	109/505 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 AFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQ----RNM--------LLGIVEGSE 110
            :|.|||:||||:|.|||..|:.||||.||.:.|::.:..:|    .||        .|.::..||
  Rat    56 SFLGIPFAKPPIGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSE 120

  Fly   111 DCLHLNVYVKALKSE-KPLPVIVWIYGGGFQKGEASRDIYSPDYF-MKKPVVFVAINYRLAALGF 173
            |||:||:|......| ..|||:|||:||....|.||  :|..... ..:.||.|.|.|||..|||
  Rat   121 DCLYLNIYTPNHAHEGSNLPVMVWIHGGALVIGMAS--LYDGSMLAAMENVVVVTIQYRLGVLGF 183

  Fly   174 LSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLF 238
            .|..|.  ...||.|..|||.||.|:.||||||.|:|:.:|:.|||||..||...:.:..:||||
  Rat   184 FSTGDQ--HARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSRGLF 246

  Fly   239 HKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDE 303
            |.|||:||.||...:.|..::..:|...||  .|.|: .|..:.::  |.|  ...::::::::
  Rat   247 HGAIMESGVALMSSLISVSSDVVYRTVANL--SGCEQ-VDSKALVN--CLR--GKSEEEIMSIN- 303

  Fly   304 VRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALK 368
             ::|.:.: |.|      |...:|:..|:||:.|..:.||.|:|.|:.|
  Rat   304 -KAFRIIS-GIV------DGIFLPRHPKELLASADFHPIPSIIGVNNDE---------------- 344

  Fly   369 NFHNILPREVRETSSLEGQD------LLVRRLKQLYFNNE-----MQESM--------------E 408
             :..|:|..:..|.|.:..|      :|.:|:.|:.:..|     ::|.|              |
  Rat   345 -YGWIIPSSMTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEYMGDSEDPQFLQVQFKE 408

  Fly   409 MFEALN-IFSHRQIWHDTHRFILARQSYAPKTPTYLYRF--------DFDSPHFNQFRRLVCGDR 464
            |.|... :....|:.|       .::|.|   |.|.|.|        |...||       |..|
  Rat   409 MMEDFTFVIPALQVAH-------FQRSNA---PVYFYEFQHRPSFFKDSKPPH-------VKAD- 455

  Fly   465 IRGVAHADELSYLFYNII-ASKLDKSSMEYKTIERMVGMWTSFASSGNPN 513
                 |.||:.::|.:.. .:::|.:..|.....||:..|.:||..||||
  Rat   456 -----HGDEILFIFRSFWGGTQVDLTEEEELLSRRMMKYWANFARQGNPN 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	160/505 (32%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	47/105 (45%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	160/505 (32%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	48/106 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640