DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and CG10175

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	194/568 - (34%)
Similarity:	297/568 - (52%)	Gaps:	62/568 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VILDTKYGQVRGLQRKTVY---DKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRS 94
            ::..|..|:|||..:|  |   ::..|::|:|:.|..||.|..||||.:|.:||.|:.:.:....
  Fly   154 IVATTSLGKVRGRYQK--YRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQ 216

  Fly    95 KPMQRNMLLGIVEGSEDCLHLNVYVKAL-----KSEKP-LPVIVWIYGGGFQKGEASRDIYSPDY 153
            ....:||:|...:|.||||.:||:...:     .:|:| |||:||::||||..|..:..:|.|||
  Fly   217 SCPHKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDY 281

  Fly   154 FMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGE 218
            .:.:.:|.|.:||||..||||:...   |.|||.||||||:||:|:..|||.|.||||.:|:.||
  Fly   282 LVAEDIVLVTLNYRLGPLGFLTAGP---DAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGE 343

  Fly   219 SAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEW-VESPDNNWAFRLAQNLGYKGDEKDADVLSF 282
            |||::||.:::.:.|.:||||:||.|||.||:.| :.:..:..|.|||.||||.|..|..|:|.|
  Fly   344 SAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDF 408

  Fly   283 LSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVI---------------EPYETDHCVVPKRHKD 332
            |.:|.|.::.......|..::.|:.:...|.||:               ||:.|.|      ..|
  Fly   409 LRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQH------PSD 467

  Fly   333 LL-SEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWAL----KNFHNILPREVRETSSLEGQDLLVR 392
            :. |:.:.:|:..:.|.|:.|.:...:.:||:|..|    .:|..::|:::..|   |..|.:.|
  Fly   468 MYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVT---ESHDRVTR 529

  Fly   393 RLKQLYFNNE---MQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFN 454
            .::..|..::   ::...||...|......|....|.|    ..:.....|.|:|||.||. ...
  Fly   530 EIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTAR----NHAKFGNAPVYMYRFSFDG-SLG 589

  Fly   455 QFRRLVCGDRIRGVAHADELSYLF-YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPE-- 516
            .::|:: |....||.|.|||.||| :......||..|||.:...|||.|||:||..|:|. |:
  Fly   590 LYKRML-GIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPT-PDSE 652

  Fly   517 --LGSAKWEAVQLKENAVEKC--FNISHDLEMRDLPESDCLAVWDTFY 560
              :.:.||..:. ..|.:...  .:||.:|.|:..||.:....||..|
  Fly   653 DPMLTTKWAPID-PTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	183/527 (35%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	52/109 (48%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	191/559 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760