DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	249/549 - (45%)
Similarity:	336/549 - (61%)	Gaps:	42/549 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQR 99
            ::|..|.|.|.|...||..| |.:||.||||:||||.|||.||.|.|||...|:||....||:|.
  Fly     6 VNTTSGPVLGKQCTGVYGDE-YVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTKPGQKPLQF 69

  Fly   100 NMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAI 164
            |.....:||.||||:||||.|.|.|.:|||:||:.:||||:||:.:::::||||||.:.||.|.:
  Fly    70 NHYSKQLEGVEDCLYLNVYAKELDSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVTV 134

  Fly   165 NYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMM 229
            :||:..||||||.||.:.||||||||||::|:.||.:|...|||||.|:|..|||||:||||.:|
  Fly   135 SYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYLM 199

  Fly   230 TTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDE--KDADVLSFLSKVCARQIA 292
            ...:..|||||||:|||..|..|......|...|||.|||.:..|  .||.||.||.|:...::
  Fly   200 LNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAMVLDFLQKLPGEKL- 263

  Fly   293 AIDQDVINLDEVRSFLL----------FAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVG 347
                       ||.:||          |.|||::|||:|:||.:|...::||.:||||.|||::.
  Fly   264 -----------VRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMS 317

  Fly   348 GNSFEGLFSYQLVRKDPWAL----KNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESME 408
            |.|||||..|..|:..|:.|    |...::||.:|:..........|.:||::.:|......:|.
  Fly   318 GTSFEGLLMYARVQMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPSAMS 382

  Fly   409 MFEALNIF----SHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVA 469
            . |:|..:    |::..||...:.:.:|.. :....|||||||||||.||..|...|||::||||
  Fly   383 P-ESLKAYCEYASYKVFWHPILKTLRSRVK-SSSASTYLYRFDFDSPTFNHQRLKYCGDKLRGVA 445

  Fly   470 HADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNC----PELGSAK-WEAVQLKE 529
            |.|:.|||:|...:.||||.:.|:.|||||:.|.||||.:.||||    .:|..|| |:.:..|
  Fly   446 HVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDMLTSFARTSNPNCKLIQDQLPRAKEWKPLNSK- 509

  Fly   530 NAVEKCFNISHDLEMRDLPESDCLAVWDT 558
            :|:| |.|||.:::|.:|||...|.||::
  Fly   510 SALE-CLNISENIKMMELPELQKLRVWES 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	234/512 (46%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	59/103 (57%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	245/539 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467362
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.890