DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	277/568 - (48%)
Similarity:	377/568 - (66%)	Gaps:	16/568 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFR 75
            :::....|..|..|.||.:...||.||.||:|:|::.:::|... |::|||||:||||||:|||:
  Fly    11 MRIALNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGNN-YYSFEGIPFAKPPVGELRFK 74

  Fly    76 APQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQ 140
            ||..||.|..|..||..|:||.|.|::|..|:||||||:||||.:.|...:||||:|||||||||
  Fly    75 APVEPEHWSDVKRCTHVRAKPCQVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQ 139

  Fly   141 KGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAH 205
            .||||||:|||||.|.:.||.|.|:|||.|||||||.|.:||||||||||||||||||:.:|...
  Fly   140 MGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQF 204

  Fly   206 FNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDN-NWAFRLAQNLG 269
            |.|||:|||:.|||||.||.|.||.|:|.:|||||.|:.||.||:.|.::|.: ||.:||||..|
  Fly   205 FGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATG 269

  Fly   270 YKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFL-LFAFGPVIEPYETDHCVVPKRHKDL 333
            |.||..|.|:.:.|.|..|..:..:.:|:|.::|....| :|:|||.||||.|.|||:||...::
  Fly   270 YTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEM 334

  Fly   334 LSEAWGNDIPVIVGGNSFEGLFSYQLVRKDP---WALKNFHNILPREVRETSSLEGQDLLVRRLK 395
            :.:.|||.||:::||||||||..:..|.|.|   ..|.:..|:.|::.....  :.:....::::
  Fly   335 MRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAPQDAHVDE--QQRKAFGKKVR 397

  Fly   396 QLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLV 460
            :|||.:.......:.|..::||::..||..||.:|:|..:||..||:||||||||.|||..|.:.
  Fly   398 ELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIIT 462

  Fly   461 CGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCP-------ELG 518
            ||.::||..|||:|||||||..|.||.:.:.|:|||:|:|.|...||.||:||.|       |..
  Fly   463 CGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQP 527

  Fly   519 SAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYPRESLF 566
            ...|..:. |::.|.:|.|||||:.:.||||::.|.:||..|.||.|:
  Fly   528 RGAWLPIS-KDDKVFQCLNISHDVHVIDLPEAEKLRLWDCIYDRELLY 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	252/502 (50%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	72/103 (70%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	266/538 (49%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	73/104 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467352
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910