DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and alpha-Est9

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	273/583 - (46%)
Similarity:	369/583 - (63%)	Gaps:	36/583 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRA 76
            |:|.::|..||||.|..|....::.|.||.::|::||::|. :.||:||.||:||||||:||::|
  Fly    11 KIGLKMVDFKVQQRRYRTSEKTVVSTTYGPIKGVKRKSIYG-QSYFSFERIPFAKPPVGELRYKA 74

  Fly    77 PQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQK 141
            |||||.|..|.:||:...||:|::.:..:.:||||||:||||.|.|...||:||:|||||||||.
  Fly    75 PQPPEVWTEVRSCTSQGPKPLQKHFVFEMTDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQF 139

  Fly   142 GEASRDIYSPDYFMKKPVVFVAINYRLAAL------------------GFLSLKDPKLDVPGNAG 188
            |||||:.|||||.:::.||.::|||||..|                  |||.|.||:||||||||
  Fly   140 GEASRECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAG 204

  Fly   189 LKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWV 253
            |||||:||||:..|.:.|.||..|||:.|:||||||||.||.||||.|||||||..||..||.|.
  Fly   205 LKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWA 269

  Fly   254 ESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEP 318
            .:|..||.:|||...||.|:....||..||......:|...:.::...:|.:..:.|:|||||||
  Fly   270 VTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEP 334

  Fly   319 YETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHN---ILPREVRE 380
            |.|.||||||:..:::..||.|:||:|:||.|.|||..|...:.:|..|....:   ::|.|:
  Fly   335 YVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIEL-- 397

  Fly   381 TSSLEGQDLLVR----RLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPT 441
              :::.:..|.|    :|:|.|:.::......:.|.|.:.||...|...:|.:|:|..||...||
  Fly   398 --NMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPT 460

  Fly   442 YLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSF 506
            |||||||||.|||..|.|.||.::||..|.|:|||||||.:|.||...:.|||.|||:||:||.|
  Fly   461 YLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHF 525

  Fly   507 ASSGNPNCPELGSAKWEAVQLKENAVE----KCFNISHDLEMRDLPESDCLAVWDTFYPRESL 565
            |:.||||........|:.|.  ..|||    ||.|||.:|::.|:|:...|.||::|:.|:.|
  Fly   526 AACGNPNFDPEQEDLWQPVD--PAAVEKHQLKCLNISDELKVIDVPDLKKLMVWESFFRRDEL 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	245/515 (48%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	67/121 (55%)
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	250/528 (47%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	67/121 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467354
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910