DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Est-Q

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	152/538 - (28%)
Similarity:	242/538 - (44%)	Gaps:	110/538 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNC------- 89
            ||.|....|.|.|....|.:....:..|.|||:|:||:.:||||.|....||.|.||.
  Fly    43 TVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC 107

  Fly    90 --TTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSPD 152
              .||....|....|       ||||.|:||.|.|.:.:  ||:.:||||||..|  |.:.:.|:
  Fly   108 PVITNLDSQMSDAEL-------EDCLTLSVYTKNLSASQ--PVMFYIYGGGFYNG--SSEDHPPN 161

  Fly   153 YFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMG 217
            |.::|.||.|...||:.|||:||....:|  ||||.:.|.:|||.|:..:|:.|.|||..:|:.|
  Fly   162 YLLEKDVVLVVPQYRVGALGWLSTYTEEL--PGNAPIADILMALDWVQMHISSFGGDPQKVTIFG 224

  Fly   218 ESAGSASVHVMMTTEQT-RGLFHKAIMQSGCALSEWVESPD-NNWAFRLAQNLGYKGDEKDADVL 280
            :|||:.....::.:.:| ..:|.:||:|||...:.|..:.| ...:.|:...||..|.|:...::
  Fly   225 QSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLV 289

  Fly   281 SFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVI 345
            ..:.|...            :|.:::....:|.|::...   |.::|::..:|: :::...||::
  Fly   290 KCIQKAKV------------IDILKATASESFSPIVGDL---HGILPQQPSELV-KSYRRQIPIL 338

  Fly   346 VGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSL------EGQDLLVRR--------LKQ 396
            .|....:|.|          .|.::::.|..:|...|||      :|.:.||..        |.:
  Fly   339 TGFTQHDGSF----------VLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNR 393

  Fly   397 LYFNNEMQESMEMFEAL--------NIFSHRQIWHDTHRFILARQSYAPK--TPTYLYRFDFDSP 451
            |.|..:...|.:...|:        |||....:      ..||.:.|..:  ||.|:|.|:::..
  Fly   394 LLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPV------ITLATKMYTQQRSTPVYVYSFEYEGT 452

  Fly   452 H-------------FNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMW 503
            :             ||           .||.|:::..|||     :.......:.:..::||.:|
  Fly   453 YTRFGYEFGNSHYPFN-----------GGVHHSNDNIYLF-----ATHPLEGQDTQMSQKMVDVW 501

  Fly   504 TSFASSGNP-NCPELGSA 520
            ||||..|.| |...|.||
  Fly   502 TSFAIEGVPRNLSPLSSA 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	152/538 (28%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/103 (44%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	152/538 (28%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	43/108 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.970