Protein Alignment alpha-Est2 and Ces3a

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 594
• Identity: 168/594 - (28%)
• Similarity: 246/594 - (41%)
• Gaps: 115/594 - (19%)

  Fly    17 LVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPE 81
            ::|.||.|..        :||..|:|||.|............|.|||:|:.|:|.|||.||.||:
Mouse    29 VIGPKVTQPE--------VDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQ 85

  Fly    82 PWQGVLNCTTNRSKPMQ-----------RNMLLGIVEGSEDCLHLNVYVKA-LKSEKPLPVIVWI 134
            ||:||.:.:.|....:|           .|..:.|...|||||.||:|... :.:....||:|||
Mouse    86 PWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWI 150

  Fly   135 YGGGFQKGEA-SRD-----IYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQV 193
            :||....|.: |.|     .|.       .||.|.:.|||...||||..|..:  |||.|..|.|
Mouse   151 HGGSLLVGSSTSHDGSALAAYG-------DVVVVTVQYRLGIFGFLSTGDKHM--PGNRGFLDVV 206

  Fly   194 MALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDN 258
            .||||:..|||.|.||||.:|:.|.|||...|..::.:..:.||||:||.|||..:|:.:|  |.
Mouse   207 AALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILE--DL 269

  Fly   259 NWAFRLAQNLGYK---GDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYE 320
            | |:..|||....   |....|:::..|.:...:.:  |.:..:|:.                |.
Mouse   270 N-AWSEAQNFANSVACGSASPAELVQCLLQKEGKDL--ITKKNVNIS----------------YT 315

  Fly   321 TDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLE 385
            .:....|:|.:.||:......:|.::|..:.|  |.        |.|..|.|||.:    ...|.
Mouse   316 VNDSFFPQRPQKLLANKQFPTVPYLLGVTNHE--FG--------WLLLKFWNILDK----MEHLS 366

  Fly   386 GQDLLVRRLKQL----------------YFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQS 434
            .:|||......|                |.:|...||...:....:.....:...|  .|.::..
Mouse   367 QEDLLENSRPLLAHMQLPPEIMPTVIDEYLDNGSDESATRYALQELLGDITLVIPT--LIFSKYL 429

  Fly   435 YAPKTPTYLYRFDFDSPHFNQFR-RLVCGDRIRGVAHADELSYLFYNIIASKLDKSSM------- 491
            .....|.:||.|......|.:|: ..|..|      |:.|.:::|.....:  |:||:
Mouse   430 QDAGCPVFLYEFQHTPSSFAKFKPAWVKAD------HSSENAFVFGGPFLT--DESSLLAFPEAT 486

  Fly   492 -EYKTIE-RMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLA 554
             |.|.:. .|:..|:.||.:||||  ..|...|..:    |.:|:...|..:.......:...|.
Mouse   487 EEEKQLSLTMMAQWSQFARTGNPN--GKGLPPWPQL----NQLEQYLEIGLEPRTGVKLKKGRLQ 545

  Fly   555 VWDTFYPRE 563
            .|....||:
Mouse   546 FWTETLPRK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	156/537 (29%)
		Aes	<117..>221	CDD:223730	44/110 (40%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	162/578 (28%)
		Aes	75..>245	CDD:223730	69/178 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832505
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740