DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and CG4382

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	178/569 - (31%)
Similarity:	277/569 - (48%)	Gaps:	82/569 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VILDTKYGQVRGLQRKTVYDKEP---YFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRS 94
            :::.|..|::||    |:...:.   ::||.|||||||||..|||:.|:|.|.|...|:.|.:..
  Fly    44 LVITTALGKIRG----TILPSQSGRNFYAFRGIPYAKPPVDRLRFQPPEPVEQWFDTLDATFDGP 104

  Fly    95 KPMQRNMLLGIVEG--SEDCLHLNVYVKALKSEKP----LPVIVWIYGGGFQ--KGEASRDIYSP 151
            |..|    ||:|.|  |||||.:|:|.|.|.||..    .||||:|:.|||.  .|: |::...|
  Fly   105 KCPQ----LGLVSGDVSEDCLRVNIYTKELPSESQPNVRRPVIVFIHPGGFYSLSGQ-SKNFAGP 164

  Fly   152 DYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLM 216
            .|||.:.:|.|..||||.:||||:  ....:.|||.||||||..|||:..:|:.|.|||::|||:
  Fly   165 QYFMNRRLVLVTFNYRLGSLGFLA--TGTREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLL 227

  Fly   217 GESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQ-NLGYKGDEKDADVL 280
            |..||:.:|.:.|.:..:||||||||:.||....:| ..||:.......| .|.:...|...:::
  Fly   228 GYGAGAMAVTLHMVSPMSRGLFHKAIVMSGAVTGQW-SLPDHQMDVATKQATLLHCHTENVTEMM 291

  Fly   281 SFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEP-YETDHCVV--PKRHKDLLSEAWGND- 341
            ..|......:.|.....:...|  |:..|..:.||||| :..:..:|  |.|       ::.||
  Fly   292 DCLKGKHYLEFANTLPKMFEFD--RNNPLILWKPVIEPDFGQERFLVEEPIR-------SYQNDD 347

  Fly   342 ---IPVIVGGNSFEGLFSYQLVRKDPWAL----KNFHNILPREVRETSSLEGQDLLVRRLKQLYF 399
               :|:|.|....|.:.....:.:.|..|    :||.::.|......:|......:.:.|:..||
  Fly   348 FMKVPIITGMTKDEFVGPALSILQSPTLLSALNENFESLAPVFFMYNTSDARACNISQELRNHYF 412

  Fly   400 NNEMQESMEMFEAL-NIFSHRQIWHDTHRFI-LARQSYAPKTPTYLYRFDF-----------DSP 451
            .:::.::....||| |::|........|||: ||.:|    |..|.|||.:           |:|
  Fly   413 PDKLIDANRSLEALSNLYSDALTGFGIHRFVHLAARS----TKVYYYRFSYQGARSHIYYPEDAP 473

  Fly   452 HFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKL-DKSSMEYKTIERMVGMWTSFASSGNPNCP 515
            :              ||.|.|:|.|||.....|:: .:...|::.::.||.|:::||..|:||.|
  Fly   474 Y--------------GVVHHDDLMYLFVEPSISRMFTEDDDEFRMVDIMVRMFSAFAYKGDPNKP 524

  Fly   516 ---ELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVWDTFYP 561
               .|...:|.....|:...   .:|...:.:.:...::...:|...:|
  Fly   525 TDLALRDIRWRPFSFKKRYY---LDIGKHITLEENLNAENYEIWKRLFP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	173/529 (33%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	50/109 (46%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	176/562 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467400
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	1	0.950	-	0	Normalized mean entropy	S4180
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.750