DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Glt

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	151/531 - (28%)
Similarity:	241/531 - (45%)	Gaps:	86/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VILDTKYGQVRGLQ-RKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSK- 95
            |:...:.||:.|:. .||:.:: |..||.||.|.....|..||:|.| |..:||.:|.|.....
  Fly    61 VVQAPEVGQILGISGHKTIANR-PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNC 123

  Fly    96 ---PMQRNMLLGIVEGS--EDCLHLNVYVKALKSEKPLPVIVWIYG-----GGFQKGEASRDIYS 150
               |....:.|....|.  :|||.|::|  |.:....|||:|:::|     ||.::.:
  Fly   124 AQFPELDRLRLSESRGENVDDCLTLDIY--APEGANQLPVLVFVHGEMLFDGGSEEAQ------- 179

  Fly   151 PDYFMKKPVVFVAINYRLAALGFLS-LKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNIT 214
            |||.::|.|:.|:||||||..|||| |.|   ::|||..|.|..:||.|:.:|:.||.|:...:|
  Fly   180 PDYVLEKDVLLVSINYRLAPFGFLSALTD---ELPGNVALSDLQLALEWLQRNVVHFGGNAGQVT 241

  Fly   215 LMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWV---ESPDNNWAF-RLAQ------NLG 269
            |:|::.|:...|.:..:.:...||.:.|:|||.||:.::   :..|....| |||:      |..
  Fly   242 LVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPS 306

  Fly   270 YKGDEKDADVLSFLSKVCARQIAAIDQ-----DVINLDEVRSFLLFAFGPVIEPYETDHCVVPKR 329
            .:|.:...|.|:.|.  .::.:||.:|     :.:.|.::..|.|....|:        ..:|.
  Fly   307 AQGLKPLYDCLARLP--TSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPL--------GFLPS- 360

  Fly   330 HKDLLSEAWGNDIPVIVGGNSFEGLFSY-----QLVRKDPWALKNFHNILPREVRETSSLEGQDL 389
            |...|:......:|:|:|.......|..     ||.|.....:.::.:::.|.....|.
  Fly   361 HPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSE------ 419

  Fly   390 LVRRL-KQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILAR--------QSYAPKTPTYLYR 445
              .|| ||...........|...:|...:...:  :...:||.|        |||. ..|.|||.
  Fly   420 --HRLWKQWALREIFTPIQEQTASLQTVAPGLL--ELSNYILYRAPVINSISQSYR-SVPAYLYT 479

  Fly   446 FDFDSPHFNQFRRLVCGDRIRGV--AHADELSYLF-YNIIASKLDKSSMEYKTIERMVGMWTSFA 507
            ||:...| ::|..| ......||  :.:|:..||| |...||:|  :.::......:|.||.:||
  Fly   480 FDYRGEH-HRFGHL-SNPLPFGVDASLSDDSVYLFPYPPEASRL--NPLDRSLSRALVTMWVNFA 540

  Fly   508 SSGNPNCPELG 518
            ::|.|| |..|
  Fly   541 TTGVPN-PSSG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	151/531 (28%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	42/109 (39%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	151/531 (28%)
		Aes	<146..345	CDD:223730	68/212 (32%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950