DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and CG5397

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001259865.1	Gene:	CG5397 / 33313	FlyBaseID:	FBgn0031327	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	124/529 - (23%)
Similarity:	216/529 - (40%)	Gaps:	116/529 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 FAFEGIPYAKPPVGDLRFRAP--------------QPPEPWQGVLNCTTNRSKPMQRNMLLGIVE 107
            ::|.|:.||:||||.||:..|              .||        |.....:..||      :.
  Fly    74 YSFLGMHYAEPPVGPLRYSRPVYKRLAGDFNATKHGPP--------CIQPHPQFPQR------II 124

  Fly   108 GSEDCLHLNVYVKALKSEKP-LPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAAL 171
            |.||||.||||...:..|.. |||.|||:.||::.|.|::  |......::..:.||..|||.:|
  Fly   125 GDEDCLLLNVYTPQMPDETTGLPVFVWIHPGGYRYGSAAQ--YDATPMAQRGAIVVAPQYRLGSL 187

  Fly   172 GFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHV--MMTTEQT 234
            |.:.  |......||..:.|...||||::..|::|.|:|..:..:|..:|:||...  |..|.::
  Fly   188 GIMG--DGTKQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMSPTSRS 250

  Fly   235 RGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKV------------- 286
            .|..|..:..||.|||:                  |..|::....:..::|:
  Fly   251 AGDVHGVVAMSGTALSQ------------------YAMDKEPVQSVQEVAKINGCPTGNELEIVN 297

  Fly   287 CARQIAAIDQDVI-NLDEVRSFLL------------FAFGPVIEPYETDHCVVPK----RHKDLL 334
            |.|..:|  :|:| |.|:|::..|            ..|.|.||. |.|...:|.    ..:..|
  Fly   298 CLRSKSA--EDIIKNDDKVQTERLAGRALVKGLTGNVGFQPHIES-EDDGRALPSLIVGEPEQQL 359

  Fly   335 SEAWGNDIPVIVGGNSFE--GLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQDLLVRRLKQ- 396
            ..:..:.||::.|....|  ...:.:.:.|...:.:.|...|...:.:.:|....|.|..::.:
  Fly   360 KSSNFSGIPLLTGVTKHETANSVTVETIEKVFGSAEQFLGSLSDSLNKLTSFLKIDKLTGQIAKP 424

  Fly   397 ------LYFNNEMQESMEMFEALNI--FSHRQIWHDTHRF-----ILARQSYAPKTPTYLYRFDF 448
                  ......:|:..::.:|||:  ...:.:...|...     :|..|.::...|.::|.|::
  Fly   425 ELPGLTSVLTPTLQDVWKVPQALNVDQVLSKVVESTTDVLFNLPAVLTTQVWSRLAPAFMYSFEY 489

  Fly   449 D---SPHFNQFRRL-----VCGDRIRGVAHADELSYLF--YNIIASKLDK----SSMEYKTIERM 499
            :   |...|..:.|     ...|:...|.|.||:.|:|  .:|..:.:::    |:.:.|....:
  Fly   490 NGTKSKGINFLKGLPIVSETAHDKPETVGHGDEIGYMFDANDIFGNPMEETRLTSAEDLKVRNNL 554

  Fly   500 VGMWTSFAS 508
            :.:...||:
  Fly   555 IDLLVKFAN 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	124/529 (23%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	34/104 (33%)
CG5397	NP_001259865.1	COesterase	62..600	CDD:278561	124/529 (23%)
CG5397	NP_001259865.1	Aes	82..>261	CDD:223730	61/196 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	5	4.810