DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and cel.1

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_955901.2	Gene:	cel.1 / 322481	ZFINID:	ZDB-GENE-030131-1201	Length:	550	Species:	Danio rerio

Alignment Length:	519	Identity:	156/519 - (30%)
Similarity:	230/519 - (44%)	Gaps:	93/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQVRGLQRKTVYDKEPYF-AFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRN 100
            |:.|.|:|..|.....:  |. .|:|||:|.||   .||..|.....|:|||..|..|.:.:|.|
Zfish    27 TEGGMVQGKSRSVGLFR--YMDTFKGIPFAAPP---KRFEKPVAHPGWEGVLKTTDYRKRCLQLN 86

  Fly   101 MLLGIVEGSEDCLHLNVYV---KALKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFM------- 155
            :|...|.||||||:||::|   :.:.|.  |||:|:||||.|..|......:..:|..
Zfish    87 LLATDVIGSEDCLYLNIWVPQGRTVSSN--LPVMVFIYGGAFLLGGGQGANFLDNYLYDGEEMAD 149

  Fly   156 KKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESA 220
            :..|:.|..|||:.||||:|..|.  .:|||.||.||..|:.|:.:||..|.|:|:||||.||||
Zfish   150 RGNVIVVTFNYRVGALGFMSTGDD--GIPGNYGLWDQHAAISWVHRNIKAFGGNPDNITLFGESA 212

  Fly   221 GSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPD-NNWAFRLAQNLGYKGDEKDADVL---- 280
            |:|||:..:.|.:.:|:..:||.|||.||..|..|.: ..:|..:|..:|...|...||.|
Zfish   213 GAASVNFQIITPKNKGMIRRAISQSGVALCPWAISRNPRQFAEEIATKVGCPIDSGMADCLKRAD 277

  Fly   281 ----SFLSKVCARQIAAIDQDVI-NLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGN 340
                :...|:  :..::.|..:: ||         ...|||     |...:|...:.|...|  .
Zfish   278 PKAVTLAGKL--KLTSSPDAPIVHNL---------YLSPVI-----DGDFIPDEPETLFGNA--A 324

  Fly   341 DIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSL-------EGQDLLVRRLKQLY 398
            ||..|.|.|..:   ::.....|..::.|.....|  |.|..:|       .|||..:...::..
Zfish   325 DIDYIAGVNDMD---AHIFATIDIPSINNALTTTP--VEEVQALATALSRDRGQDAGIATFQEYT 384

  Fly   399 FN-----NEMQESMEMFEALNIFSHRQIWHDTHRFILARQS-------YAPKTPTYLYRFDFDS- 450
            .|     |:.:....:.|.          ...:.|::..|:       .|....|:.|.|...|
Zfish   385 VNWGDKPNKEKVKQTVVEL----------ETDYMFLVPTQAALYLHTDNAKSARTFSYLFTESSR 439

  Fly   451 -PHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPN 513
             |.|..:         .|..|||||.|:|....|:.|..........:.|:..|::||.:|:||
Zfish   440 IPVFPLW---------MGADHADELQYVFGKPFATPLGYFPRHRDVSKYMIAYWSNFAQTGDPN 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	156/519 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/113 (40%)
cel.1	NP_955901.2	COesterase	25..517	CDD:306613	156/519 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650