Protein Alignment alpha-Est2 and CES4A

DIOPT Version :10

• Sequence 1: NP_524268.3
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 165/608 - (27%)
• Similarity: 261/608 - (42%)
• Gaps: 128/608 - (21%)

  Fly    37 TKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT---------- 91
            ||||.::|.|...  .|.|...|.|:|:::||:|.|||..|:|||||:|:.:.||
Human    54 TKYGTLQGKQMHV--GKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALS 116

  Fly    92 -------------NRSKPMQRNML---LGI--------------------------VEGSEDCLH 114
                         ..:..:|.::|   |.|                          :..|||||:
Human   117 PGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLY 181

  Fly   115 LNVYVKALKSEKP-LPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKD 178
            ||||..|.....| |||:||..||.|..|.|| .....|...::.||.|.:.:||...|||..:.
Human   182 LNVYAPARAPGDPQLPVMVWFPGGAFIVGAAS-SYEGSDLAAREKVVLVFLQHRLGIFGFLRWRG 245

  Fly   179 PKLD--VPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKA 241
            ...|  ..||.||.||:.||||:.:|||.|.|||.|:||.|:|||:.|:..:|.:....||||:|
Human   246 RTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRA 310

  Fly   242 IMQSGCALSE-WVESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDV----INL 301
            |.|||.||.. ::.|.....|.::|...|...:.... :::.|..:...::..:...:    :|.
Human   311 ISQSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQI-LVNCLRALSGTKVMRVSNKMRFLQLNF 374

  Fly   302 DEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNS--FEGLFSY------- 357
            ......::::..||:     |..|:|.....||::...:.:|.::|.|:  |..|..|
Human   375 QRDPEEIIWSMSPVV-----DGVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLN 434

  Fly   358 -QLVRKDP-----WALKNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMF------ 410
             |.:||:.     |:.:...||...:|         .|:|..    |.:|..:...:|.
Human   435 RQAMRKETITKMLWSTRTLLNITKEQV---------PLVVEE----YLDNVNEHDWKMLRNRMMD 486

  Fly   411 ---EALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHAD 472
               :|..:::..|..| .||        ....|.|||.|:      :..|.::...|..|..|.|
Human   487 IVQDATFVYATLQTAH-YHR--------DAGLPVYLYEFE------HHARGIIVKPRTDGADHGD 536

  Fly   473 ELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFN 537
            |:.:||....|:.|.....:..::: |:..|.:||.:||||...|..  |......|..::..|.
Human   537 EMYFLFGGPFATGLSMGKEKALSLQ-MMKYWANFARTGNPNDGNLPC--WPRYNKDEKYLQLDFT 598

  Fly   538 ISHDLEMRDLPESDCLAVWDTFY 560
            ....:::::..    :|.|.:.|
Human   599 TRVGMKLKEKK----MAFWMSLY 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_524268.3	COesterase	34..556	CDD:395084	163/602 (27%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	163/602 (27%)