DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	170/568 - (29%)
Similarity:	256/568 - (45%)	Gaps:	97/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GWPKLIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVG 70
            ||..::..|..|:   :|........:.|.:|..|||||........|.....|.|||:||||||
  Rat     8 GWLYVVACGLLLL---LQHVHGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVG 69

  Fly    71 DLRFRAPQPPEPWQGVLNCTTNRSKPMQRNM--LLGIVE---------GSEDCLHLNVYVKALKS 124
            .|||..|:.||||.||.:.|:..:..:|.::  |.||.|         .|||||:||:|..|...
  Rat    70 PLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAR 134

  Fly   125 E-KPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAG 188
            | ..|||:|||:|||...|.||.:..| .....:.:|.|:|.|||..|||.|..|.  :..||.|
  Rat   135 EGSNLPVMVWIHGGGLVLGSASMNDAS-TLAATEEIVIVSIQYRLGVLGFFSTGDQ--NARGNWG 196

  Fly   189 LKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWV 253
            ..|||.||||:.||||:|.|:...:|:.|.|||..||...:.:..::||||.||||||.||...:
  Rat   197 YLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDL 261

  Fly   254 ESPDNNWAFRLAQNL-GYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIE 317
            .|..:...::...|| |.:..:.:|.:.      |.|  |...|:::.:::|...:
  Rat   262 ISDKSEVVYKTVANLSGCEAPDSEALIR------CLR--AKSKQEILAINQVFKMI--------- 309

  Fly   318 PYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFE-GLFSYQLVRKDPWALKNF---HNILPREV 378
            |...|...:||..::||:....:.:|.|:|.|:.| |           |.:..|   .:|:.:..
  Rat   310 PGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECG-----------WGIPVFLGLDHIIKKIT 363

  Fly   379 RET-----SSLEGQ--------DLLVRRLK---------QLYFNNEMQESMEMFEALNIFSHRQI 421
            |||     .|...|        ||::....         |..|.:.:.:.|.:..||.: :|.|
  Rat   364 RETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVIPALQV-AHFQ- 426

  Fly   422 WHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNII-ASK 485
                          ..:.|.|.|.|.    |...|.:.|....:: ..|.|::.::|.:.: ...
  Rat   427 --------------RSQAPVYFYEFQ----HLPSFIKQVRPSHVK-ADHGDDILFVFGSYLWGMT 472

  Fly   486 LDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533
            .|.:..|.....|::..|.:||.:||||..:|  ..|..:...|..::
  Rat   473 FDLTEEEELLKRRVMKYWANFARTGNPNGEDL--PHWPVLDHDEQYLQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	163/530 (31%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	46/104 (44%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	165/543 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840