Protein Alignment alpha-Est2 and Nlgn3

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_766520.2
• Gene: Nlgn3 / 245537
• MGIID: 2444609
• Length: 825
• Species: Mus musculus
• Alignment Length: 611
• Identity: 174/611 - (28%)
• Similarity: 265/611 - (43%)
• Gaps: 150/611 - (24%)

  Fly    35 LDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN-------C 89
            ::|.:|::||  .:.....|   |...:.|:|||.||:|:.||..|:||..|.|:.|       |
Mouse    41 VNTHFGKLRG--ARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVC 103

  Fly    90 TTNRSKPMQRNML-------LGIV-----EGSEDCLHLNVYVK------ALKSEKPL-------- 128
            ..|....:...||       |.||     |.:||||:|||||.      |.|..:.|
Mouse   104 PQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDED 168

  Fly   129 ---------PVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVP 184
                     ||:|:|:||.:.:|..:. |..........|:.:.:|||:..|||||..|..  ..
Mouse   169 EDIRDSGAKPVMVYIHGGSYMEGTGNM-IDGSVLASYGNVIVITLNYRVGVLGFLSTGDQA--AK 230

  Fly   185 GNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCAL 249
            ||.||.||:.||||:|:|||.|.|||..||:.|...|::.|.::..:..:.|||.:||:|||.||
Mouse   231 GNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSAL 295

  Fly   250 SEW-VESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKV-CARQIAA---IDQDVINLDEVRSFLL 309
            |.| |......:...||..:|       .:||..:..| |.||.:|   ::||:   ...|..:
Mouse   296 SSWAVNYQPVKYTSLLADKVG-------CNVLDTVDMVDCLRQKSAKELVEQDI---QPARYHV- 349

  Fly   310 FAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGL-FSYQLVRKDP--------- 364
             ||||||     |..|:|...:.|:.:....:..:::|.|..||| |...:|  ||
Mouse   350 -AFGPVI-----DGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVV--DPEDGVSGTDF 406

  Fly   365 -WALKNFHNIL---PREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFE--ALNIFSHRQ--- 420
             :::.||.:.|   |         ||:|.|...:|.:|.:...:::.|...  .:.:|:..|
Mouse   407 DYSVSNFVDNLYGYP---------EGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVE 462

  Fly   421 ---IWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLF---- 478
               :..|.|    ||..    :|||.|.|   ..|.....:....|    .||.||:.|:|
Mouse   463 PSVVTADLH----ARYG----SPTYFYAF---YHHCQSLMKPAWSD----AAHGDEVPYVFGVPM 512

  Fly   479 ---YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISH 540
               .::......|:.:....:  ::..||:||.:|:||.|.....|:  :..|.|..|:
Mouse   513 VGPTDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNKPVPQDTKF--IHTKANRFEE------ 567

  Fly   541 DLEMRDLPESDCLAVWDTFYPRESLF 566
                         ..|..:.||:.|:
Mouse   568 -------------VAWSKYNPRDQLY 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	167/566 (30%)
		Aes	<117..>221	CDD:223730	45/126 (36%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	174/611 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..668

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740