DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Cel

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	152/505 - (30%)
Similarity:	227/505 - (44%)	Gaps:	62/505 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQVRGLQRK-TVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQRN 100
            |:.|.|.|:.:| ::...:....|:|||:|....    ...||....|||.|..|..:.:.:|..
  Rat    28 TEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGWQGTLKATDFKKRCLQAT 88

  Fly   101 MLLGIVEGSEDCLHLNVYVKALKSE--KPLPVIVWIYGGGFQKGEASRDIYSPDYF-------MK 156
            :......|.||||:||::|...:.:  ..|||:||||||.|..|......:..:|.       .:
  Rat    89 ITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATR 153

  Fly   157 KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAG 221
            ..|:.|..|||:..|||||..|..|  |||.||:||.||:.|:.:|||.|.|||:|||:.|||||
  Rat   154 GNVIVVTFNYRVGPLGFLSTGDANL--PGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAG 216

  Fly   222 SASVHVMMTTEQTRGLFHKAIMQSGCALSEWV--ESPDNNWAFRLAQNLGYKGDEKDADVLSFLS 284
            :|||.:...:...:||..:||.|||.|||.|.  |:| ..||..:|:.:|.. .|..|.:...|.
  Rat   217 AASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENP-LFWAKTIAKKVGCP-TEDTAKMAGCLK 279

  Fly   285 KVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGN 349
            ....|.:....:..:...|.......||.||:     |...:|....:|...|  .||..:.|.|
  Rat   280 ITDPRALTLAYRLPLKSQEYPIVHYLAFIPVV-----DGDFIPDDPINLYDNA--ADIDYLAGIN 337

  Fly   350 SFEG-LFS-----------YQLVRKDPWALKNFHNILPREVRETSSLEGQ----DLLVRRLKQLY 398
            ..:| ||:           ..:..:|.:.|.:.|.:       ...|:|.    |:......|..
  Rat   338 DMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTV-------AKGLKGTQATFDIYTESWAQDP 395

  Fly   399 FNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGD 463
            ....|::::..||...:|     ...|...:...:::|....||.|.|...|       |:....
  Rat   396 SQENMKKTVVAFETDILF-----LIPTEMALAQHRAHAKSAKTYSYLFSHPS-------RMPIYP 448

  Fly   464 RIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPN 513
            :..|..|||:|.|:|....|:.|...:.:....:.|:..||:||.||:||
  Rat   449 KWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	152/505 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	48/112 (43%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	152/505 (30%)
		Aes	<118..>247	CDD:223730	62/130 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640