Protein Alignment alpha-Est2 and CES3

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 170/568 - (29%)
• Similarity: 245/568 - (43%)
• Gaps: 127/568 - (22%)

  Fly    28 STGHTVI---LDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNC 89
            :||..|.   :||..|:|||.|............|.|||:|:||:|..||.||.|.:||:||.:.
Human    26 ATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDA 90

  Fly    90 TTNRSKPM----------QRNMLLG---IVEGSEDCLHLNVYVKALKSEKPL----PVIVWIYGG 137
            :|  :.||          .|.:|.|   |...|||||.||||..|   |.|.    ||:||::||
Human    91 ST--APPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPA---EVPAGSGRPVMVWVHGG 150

  Fly   138 GFQKGEA-SRD-----IYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMAL 196
            ....|.| |.|     .|.       .||.|.:.|||..|||.|..|.  ..|||.|..|.|.||
Human   151 ALITGAATSYDGSALAAYG-------DVVVVTVQYRLGVLGFFSTGDE--HAPGNQGFLDVVAAL 206

  Fly   197 RWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESP----D 257
            ||:.:|||.|.||.|.:|:.|.|||.:.:..::.:....||||:||.|||.     :.:|    .
Human   207 RWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGV-----ITTPGIIDS 266

  Fly   258 NNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQ----DVINLDEVRSFLLFAFGPVIEP 318
            :.|.  |||        |.|:.|:..|...|..:..:.|    :::...::::        .|.|
Human   267 HPWP--LAQ--------KIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKN--------TIYP 313

  Fly   319 YETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPRE---VRE 380
            ...|..|.||..|:||.|...:.:|.::|.|:.|  ||:.:.|  .|.|.:....:.||   ...
Human   314 LTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHE--FSWLIPR--GWGLLDTMEQMSREDMLAIS 374

  Fly   381 TSSLEGQDLLVRRL-----KQLYFNNEMQESMEMFEA------LNI----FSHRQIWHDTHRFIL 430
            |..|...|:....:     :.|..|::.|...:.|:.      :|:    ||         |::
Human   375 TPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFS---------RYL- 429

  Fly   431 ARQSYAPKTPTYLYRFDFDSPHFNQFR-RLVCGDRIRGVAHADELSYLFYNIIASKLDKSSM--- 491
             |.|   .:|.:.|.|......|.:.: ..|..|      |..|.:::|.....  :|:||.
Human   430 -RDS---GSPVFFYEFQHRPSSFAKIKPAWVKAD------HGAEGAFVFGGPFL--MDESSRLAF 482

  Fly   492 -----EYKTIE-RMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533
                 |.|.:. .|:..||.||.:|:||...|  ..|......|..:|
Human   483 PEATEEEKQLSLTMMAQWTHFARTGDPNSKAL--PPWPQFNQAEQYLE 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	165/552 (30%)
		Aes	<117..>221	CDD:223730	47/113 (42%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	167/562 (30%)
		Aes	<129..>247	CDD:223730	49/129 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790