DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	576	Identity:	166/576 - (28%)
Similarity:	257/576 - (44%)	Gaps:	135/576 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCT-------- 90
            ::||.:|:|.|.........:|...|.|||:||||:|.|||..|||.|||..|.|.|
Mouse    25 VVDTAHGKVLGKHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQ 89

  Fly    91 ------------TNRSKPMQRNMLLGIVEGSEDCLHLNVYVKA-LKSEKPLPVIVWIYGGGFQKG 142
                        |||.:.:.       :|.|||||:||:|..| ......|||:|||:|||.:.|
Mouse    90 DAARGQAVNDLITNRKEKIH-------LEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLG 147

  Fly   143 EASR------DIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQ 201
            .||.      ..|       :.||.|||.|||:..||.|..|.  ...||.|..|||.||.|:..
Mouse   148 GASSFDGRALSAY-------ENVVVVAIQYRLSIWGFFSTGDE--HSRGNWGHLDQVAALHWVQD 203

  Fly   202 NIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPD-NNWAFRLA 265
            |||:|.|||.::|:.|||||..||.:::.:..::.|||:||.:||.|....:.:.| .....::|
Mouse   204 NIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIA 268

  Fly   266 QNLGYK-----------GDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPY 319
            ...|.|           ..:.:.::|..:.|:...:: ::..|..|.|:..:.:|
Mouse   269 VTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKL-SLQGDTKNSDQFVTSVL---------- 322

  Fly   320 ETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFE-GLFSYQLVRKDPWALKNFHNILPREVR---- 379
              |..|:||..|::|:|...|.:|.|||.|..| |           |.|......||.:|:
Mouse   323 --DGVVLPKDPKEILAEKNFNTVPYIVGINKQECG-----------WLLPTMTGFLPADVKLDKK 374

  Fly   380 -------ETSSLEG--QDLLVRRLKQLYFNNEMQESME--MFEALNIFSHRQIWHDTHRFILARQ 433
                   :.:|:.|  :|::...:::....::..:.:.  :.:|:.     .:.......|::|.
Mouse   375 KAIALLEQFASMTGIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMG-----DVAFGVPSVIVSRG 434

  Fly   434 SYAPKTPTYLYRF----DFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKL--DKSSME 492
            ......|||:|.:    .|.||   |..:.|.||      |||::    |::..:.:  :.:|.|
Mouse   435 HRDTGAPTYMYEYQYYPSFSSP---QRPKNVVGD------HADDV----YSVFGAPILREGASEE 486

  Fly   493 YKTIERMV-GMWTSFASSGNPN---CP------------ELGSAKWEAVQLKENAV 532
            ...:.:|| ..|.:||.:||||   .|            .:|....:|.:|||..|
Mouse   487 EINLSKMVMKFWANFARNGNPNGKGLPHWPKYDQKEGYLHIGGTTQQAQRLKEEEV 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	161/565 (28%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	47/110 (43%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	166/576 (29%)
		Aes	<121..>225	CDD:223730	49/112 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650