DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and Nlgn2

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	620	Identity:	181/620 - (29%)
Similarity:	273/620 - (44%)	Gaps:	148/620 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT---- 91
            :::|.||:|||::|:  .:.|   |...|.|:|||.||:|..||:.|:.|..|.||.|.||
Mouse    43 VVNTAYGRVRGVRRE--LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPA 105

  Fly    92 ---NRSKPMQRNML------------LGIVEGSEDCLHLNVYVKALKSEKPL------------- 128
               |....:...||            ..:...|||||:||:||..  .:.||
Mouse   106 CPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPT--EDGPLTKKRDEATLNPPD 168

  Fly   129 ---------PVIVWIYGGGFQKGEASR------DIYSPDYFMKKPVVFVAINYRLAALGFLSLKD 178
                     ||:::::||.:.:|..:.      ..|.       .|:.|.:||||..|||||..|
Mouse   169 TDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVVTLNYRLGVLGFLSTGD 226

  Fly   179 PKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIM 243
            ..  ..||.||.||:.||||:|:|||||.|||..||:.|..||::.|::::.:..:.|||.|||.
Mouse   227 QA--AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIA 289

  Fly   244 QSGCALSEW-VESPDNNWAFRLAQNLGYKGDEKDA-DVLSFLSKVCARQIAAIDQDVINLDEVRS 306
            |||.|:|.| |......:...||..:|.  |.:|: :.:..|.:..:|::  :||||   ...|.
Mouse   290 QSGTAISSWSVNYQPLKYTRLLAAKVGC--DREDSTEAVECLRRKSSREL--VDQDV---QPARY 347

  Fly   307 FLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGL-FSYQLVRKD------- 363
            .:  |||||:     |..|||...:.|:.:....:..:::|.|..||| |.......:
Mouse   348 HI--AFGPVV-----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASA 405

  Fly   364 -PWALKNFHNIL---PREVRETSSLEGQDLLVRRLKQLYF------NNEMQESMEMFEALNIFSH 418
             .:.:.||.:.|   |         ||:|:|...:|.:|.      |.||:..    ..|.:|:.
Mouse   406 FDFTVSNFVDNLYGYP---------EGKDVLRETIKFMYTDWADRDNGEMRRK----TLLALFTD 457

  Fly   419 RQIWHDTHRFILARQSYAPKTPTYLYRFDFDSP-HFNQFRRLVCGDRIR----GVAHADELSYLF 478
            .| |            .||...|.....|:.|| :|..|.. .|....|    ..||.|||.|:|
Mouse   458 HQ-W------------VAPAVATAKLHADYQSPVYFYTFYH-HCQAEGRPEWADAAHGDELPYVF 508

  Fly   479 -------YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKW---------EAVQL 527
                   .::......|:.:....:  ::..||:||.:|:||.|.....|:         |.|..
Mouse   509 GVPMVGATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWS 571

  Fly   528 KENAVEKCF-NISHDLEMRDLPESDCLAVWDTFYP 561
            |.|:.||.: :|.....:||...::.:|.|....|
Mouse   572 KFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	169/579 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	44/131 (34%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	179/613 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740