DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	173/566 - (30%)
Similarity:	257/566 - (45%)	Gaps:	84/566 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVQVGWPKLIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYA 65
            :|...||...:..|..|:..:||.   ....:.|.:|..|||||........|.....|.|||:|
  Rat     3 LESLPGWLNAVVWGLLLLFCQVQG---QDSASPIRNTHTGQVRGSFVHVKDTKSGVHTFLGIPFA 64

  Fly    66 KPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPMQR-----------NMLLGIVEGSEDCLHLNVYV 119
            |||:|.|||..|:|||||.||.:.|::.:..:|.           .|....|..|||||:|::|.
  Rat    65 KPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVSMSEDCLYLSIYT 129

  Fly   120 KA-LKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLKDPKLD 182
            .| ...:..|||:|||:|||...|.||  .|....... :.||.|.|.|||..|||.|..|.  .
  Rat   130 PAHTHKDSNLPVMVWIHGGGLCWGMAS--TYDGSMLAAIEDVVVVTIQYRLGILGFFSTGDE--H 190

  Fly   183 VPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGC 247
            ..||.|..|||.||||:.|||.||.|:|:.:|:.|||||..||...:.:..::||||.|||:||.
  Rat   191 ARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGV 255

  Fly   248 ALSEWVESPDNNWAFRLAQNL-GYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFA 311
            ||...:.|..:...:.:..|| |.:..:.:| ::|.|.:....::.||:..|..:..|
  Rat   256 ALLPNLISNTSEVIYTMVANLSGCEPVDSEA-LMSCLREKSEEEMLAINNIVRTISGV------- 312

  Fly   312 FGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPR 376
                     .|...:|:...:||:....:.:|.|:|.||.|..:...::..|. .:|..:....|
  Rat   313 ---------VDGKFLPRHPLELLASVDFHPVPSIIGINSDEYGWIIPMLHPDS-TMKEINRETMR 367

  Fly   377 EVRETSSL------EGQDLLVR---------RLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTH 426
            .|.:.:::      |..|||:.         :..|:.||..|.:.:.:..||.: :|.|..|
  Rat   368 AVLKNTAVQMMLPPECSDLLMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQV-AHFQRSH--- 428

  Fly   427 RFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADEL----SYLFYNIIASKLD 487
                        .|.|.|.|.    |.:.|.:.:....:: ..|.|||    .|||:::   |..
  Rat   429 ------------APVYFYEFQ----HQSNFLKDIRPPHVK-ADHGDELPYVIGYLFWDM---KFV 473

  Fly   488 KSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533
            .:..|.....:|:..|.:||..||||..  |...|.|:...|..::
  Rat   474 FTEEEKLLSRKMIKYWANFARHGNPNSE--GLPYWPALDHDEQYLQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	163/523 (31%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	48/105 (46%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	166/536 (31%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	49/106 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640