Protein Alignment alpha-Est2 and Nlgn1

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 662
• Identity: 171/662 - (25%)
• Similarity: 270/662 - (40%)
• Gaps: 196/662 - (29%)

  Fly    27 LSTGHTV---------ILDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQP 79
            |.|.|.:         ::.|.:|::||::::  .:.|   |...|.|:|||.||.|:.||:.|:|
Mouse    38 LQTFHVLSQKLDDVDPLVTTNFGKIRGIKKE--LNNEILGPVIQFLGVPYAAPPTGEHRFQPPEP 100

  Fly    80 PEPWQGVLNCTTNRSKPM-QRNMLLG---------------------IVEGSEDCLHLNVY---- 118
            |.||..:.|.|  :..|: .:|::.|                     :.:.|||||:||:|
Mouse   101 PSPWSDIRNAT--QFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTE 163

  Fly   119 -VKALKSE---------------------------------------KPLPVIVWIYGGGFQKGE 143
             ||.:..|                                       .|.||:|:|:||.:.:|
Mouse   164 DVKRISKECARKPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEG- 227

  Fly   144 ASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFN 207
             :.::|....... ..|:.:.:||||..|||||..|..  ..||.||.|.:.||||.|:||..|.
Mouse   228 -TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQA--AKGNYGLLDLIQALRWTSENIGFFG 289

  Fly   208 GDPNNITLMGESAGSASVHVMMT---------TEQTRGLFHKAIMQSGCALSEW-VESPDNNWAF 262
            |||..||:.|..||.:.|:::..         :..|:|||.:||.|||.|||.| |......:|.
Mouse   290 GDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYAR 354

  Fly   263 RLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVP 327
            .||..:|....: ..:::..|.|...:::  :||||   ...|..:  ||||||     |..|:|
Mouse   355 ILATKVGCNVSD-TVELVECLQKKPYKEL--VDQDV---QPARYHI--AFGPVI-----DGDVIP 406

  Fly   328 KRHKDLLSEAWGNDIPVIVGGNSFEGL-FSYQLVRKD--------PWALKNFHNIL---PREVRE 380
            ...:.|:.:....:..:::|.|..||| |...:|..|        .:|:.||.:.|   |
Mouse   407 DDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYP----- 466

  Fly   381 TSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTH------RFILA----RQSY 435
                ||:|:|...:|.:|.:                     |.|.|      :.:||    .|..
Mouse   467 ----EGKDVLRETIKFMYTD---------------------WADRHNPETRRKTLLALFTDHQWV 506

  Fly   436 APKTPTYLYRFDFDSP-HFNQFRRLVCGDRI---RGVAHADELSYLF-------YNIIASKLDKS 489
            ||...|.....:|.|| :|..|......|::   ...||.||:.|:.       ..:......|:
Mouse   507 APAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKN 571

  Fly   490 SMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLA 554
            .:....:  ::..||:||.:|:||.|.....|:  :..|.|..|:                   .
Mouse   572 DVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKF--IHTKPNRFEE-------------------V 613

  Fly   555 VWDTFYPRESLF 566
            .|..:..::.|:
Mouse   614 AWTRYSQKDQLY 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	163/612 (27%)
		Aes	<117..>221	CDD:223730	43/148 (29%)
Nlgn1	XP_006535478.1	COesterase	53..646	CDD:365897	168/647 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740