DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and cest-28

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	163/579 - (28%)
Similarity:	248/579 - (42%)	Gaps:	150/579 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HTVILDTKYGQVRG----LQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT 91
            |:..|:...|.::|    :..|||   :.|.   |||:|||.|   ||:.|:|...|:.|.:||.
Worm    13 HSEKLNATCGPIQGNVYRIGDKTV---DGYL---GIPFAKPLV---RFKKPEPAGTWEEVRDCTK 68

  Fly    92 NRSKPMQRNMLLGIVEGSED-------CLHLNVYVKALKSE---KPLPVIVWIYGGGFQKGEASR 146
            ...:..|.......:...:|       ||.|||:.|...|:   |..||:|:|:|||:: ..|||
Worm    69 YGPRCPQSGPFAEAINFQKDDIPDEANCLTLNVFSKISDSKNFNKTRPVMVYIHGGGYE-CSASR 132

  Fly   147 DIYSPDYFMK-----KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHF 206
            |..  ||.:.     |.||.|.:|||:..|||.:..|..  .|||..|.|..:.|.||.::|..|
Worm   133 DYC--DYSVAGTLPLKDVVVVTLNYRVGILGFFTTGDTV--CPGNFALWDLTLGLNWIQKHIESF 193

  Fly   207 NGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWA---FRLAQNL 268
            .|||.|||:.|:|||:|.|.::..:..:|.||::.|:.||.||.|:.....|:.|   :..|::|
Worm   194 GGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEFARHL 258

  Fly   269 GYKGDEKD-------ADVLSFLSKVCARQIAA---------IDQDVI--NLDEVRSFLLFAFGPV 315
            ||.|....       :..|..:.|:...|:.|         :|.|..  :|||:|      .|
Worm   259 GYDGTNSQTLFNWMKSKPLEEIEKMNGFQVPASGILAWTPNLDDDFFPKSLDELR------IG-- 315

  Fly   316 IEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPW----ALKNFHN---- 372
                      .||  ||           :::|....|||| ::.:.|||.    |||.:.|
Worm   316 ----------APK--KD-----------IMMGFAEHEGLF-FEFLIKDPTPPLEALKLYVNEYYK 356

  Fly   373 ----------------ILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSH-RQ 420
                            ...|.|.:|.....::.|:..:....|...:.::     |.|...| ..
Worm   357 KDTGDHFEATRNKIIEFYSRNVEDTDEKSTKERLIDFVGDALFTAGVFDN-----AKNCLKHGNN 416

  Fly   421 IWHDTHRFILARQSYAPKTPTYLYRFDFDSP----HFNQFRRLVCGDRIRGVAHADELSYLFYNI 481
            :|                    ||.||:.:|    :..:|...|      ...|..:|.|:....
Worm   417 VW--------------------LYIFDYCNPSGFGNQEEFMTFV------APTHCTDLRYVLGEG 455

  Fly   482 IASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISH 540
            :.|....:..|:|.||:|..::::||..||||  |.||::||...| :|. .:.|.||:
Worm   456 LYSDFQPTEEEHKMIEKMTTIYSNFAKYGNPN--EHGSSEWEKFTL-DNP-RRHFQISY 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	155/559 (28%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	46/111 (41%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	162/575 (28%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	47/114 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720