DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and cest-7

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001257187.1	Gene:	cest-7 / 182819	WormBaseID:	WBGene00007693	Length:	606	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	136/524 - (25%)
Similarity:	221/524 - (42%)	Gaps:	92/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSTGHTVILDTKYGQVRGLQRKTVYDKEPY-FAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN-- 88
            ||.....:|:|.||:|||:  ....||..: :.|:|||:||||:|.|||..|:.|..|.|||:
Worm    32 LSVKSFKVLNTNYGKVRGI--TDFSDKRNHKYIFKGIPFAKPPLGLLRFALPEEPNTWNGVLDGS 94

  Fly    89 -----CTTNRS--KPMQRNMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASR 146
                 |.:|.|  ...|.|:       |||||::|::..........||:|:.:||.|....|:.
Worm    95 KYSAACLSNSSLASAQQENI-------SEDCLYINIFTSEYCLAHKCPVLVYYHGGSFNLDSATM 152

  Fly   147 --DIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGD 209
              |.:..:.::...:||....|||...|...|.:..: ||.|..:.|.:.:|.::..|||.|.||
Worm   153 FPDKFILERYVDSGIVFAIPAYRLGVFGQFYLGEQGI-VPANLLIHDCIRSLNFVHDNIASFGGD 216

  Fly   210 PNNITLMGESAGSASVHVMMTTEQ---TRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQ--NLG 269
            ||.:||||.|:|...|:.|..:.|   .:.||.:.|:.|...:..:.:....| ::.:|:  |..
Worm   217 PNYVTLMGHSSGGQLVNAMGFSNQIDPEKKLFQQFIVLSSIGMYGFEDLQIGN-SYEIARRHNCT 280

  Fly   270 YKGDEKDADVLSFLSKVCARQIAAID--QDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKD 332
            .:..::..|        |.|.|.|:.  |....:|:|.  |||....:..|...|   |.::..:
Worm   281 SENSQEIVD--------CMRNIDALQLLQTQTVMDDVD--LLFFKAIIRAPPLMD---VKQKLSE 332

  Fly   333 LLSEAWGNDIPVIVGGNSFEGLFSYQ---------LVRKDPWALKN-----FHNILPREVRETSS 383
            ........::...|..|.|. :|.|.         |..::|....|     |.||.|..|...||
Worm   333 FKENVTARNMLCGVTDNEFT-IFKYPDGYYISATFLDFENPVDTVNVYRNKFTNITPTFVNSDSS 396

  Fly   384 L--------------EGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQS 434
            .              .|.::.:...:|..|:..:.: |:.|    |..||:..|.|...||  .|
Worm   397 AVFVSAATYSEALTNAGGNVYLFESRQKPFSMHVTD-MQYF----IGIHREKNHTTDMDIL--DS 454

  Fly   435 YAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERM 499
            :..|......:|...||::.::             ...:::::...|...:..:..||....|.:
Worm   455 FYSKLLVNFTKFGSPSPNWEKY-------------DPSKMNFMAMEIDTEQGIEPKMENGFHEEL 506

  Fly   500 VGMW 503
            |..|
Worm   507 VNFW 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	134/519 (26%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	33/105 (31%)
cest-7	NP_001257187.1	Abhydrolase	34..510	CDD:304388	133/520 (26%)
cest-7	NP_001257187.1	Aes	<135..>236	CDD:223730	35/101 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840