DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and cest-30

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	155/576 - (26%)
Similarity:	236/576 - (40%)	Gaps:	110/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNC--------T 90
            ||:...|.:||...|.....:....:.|||:||.|||.|:|:.|...|.|....:|        .
Worm    33 ILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVGALKFKKPVAAEKWTEPRDCYEYGPGCPQ 97

  Fly    91 TNRSKPMQRNMLLGIVEGSEDCLHLNVYV---KALKSEKPLPVIVWIYGGGFQKGEASRDIYSPD 152
            |.|...:.........|  |:||.|||:.   |..:..|.|||:|:|||||::.|..|   |..|
Worm    98 TGRFAALTAKSTAAFAE--ENCLTLNVFAPRWKLAEFPKGLPVLVYIYGGGYEIGFTS---YMDD 157

  Fly   153 YFMK-----KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNN 212
            |.:.     |.|:.|.:||||..||||::.|...:  ||.||.||.:||:|:..|||.|.|:|.:
Worm   158 YSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIAN--GNYGLWDQTLALQWVQDNIASFGGNPES 220

  Fly   213 ITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFR-----------LAQ 266
            :||.|.|||:.|...:..:..:..||.::|..||.|..        |:|.|           .||
Worm   221 VTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFC--------NFAIRPKDVEVGVCKEFAQ 277

  Fly   267 NLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFG--PVIEPYETDHCVVPKR 329
            ..||.|.:..:....:::           |:|....||..|...|.|  |.|..::.|  ..||.
Worm   278 FQGYTGTDSQSLFDWYMA-----------QNVSKFKEVAGFQSTAAGAVPFIPNFDGD--FFPKP 329

  Fly   330 HKDLLSEAWGND--IPVI----VGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQD 388
            ...|..||...|  |.|:    ||...|..||:.        |..||...    :.||...:..|
Worm   330 FDILRREAPKKDALITVVTMESVGMIIFNPLFAN--------AYNNFEGF----INETYGPDVTD 382

  Fly   389 L---LVRRLKQLYFN--NEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDF 448
            .   :.::|...|..  |...::......::..|.......|...:.:...|..|  .||..|::
Worm   383 YYADVKKKLTGFYLKDVNASDKATVNRRVVDYVSDSVFNSGTLDAVKSYVKYGNK--VYLGSFNY 445

  Fly   449 DSPHFNQFRRLVCGDRI------RGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFA 507
                ||...:    |.:      :..:|:.:..|.|.:.:.:....:..|.:.::....:..:|.
Worm   446 ----FNDATK----DMVELMQPFKEASHSSDFKYYFGSGVMANFTPTDEEMEVMDMSGTLMANFV 502

  Fly   508 SSGNPNCPELGSAKWEAVQ-LKENAVEK-----CFNISHDLEMRDLPESDCLAVWD 557
            ..|:|| .:.|:..|:... ||.|...|     |       ||.|..::..|.::|
Worm   503 KYGDPN-GKSGTKPWKPYTILKPNMYYKIDYPTC-------EMSDNFQNGRLRIYD 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	144/534 (27%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	48/111 (43%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	152/563 (27%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	49/112 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650