DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est2 and cest-16

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_741812.2	Gene:	cest-16 / 180905	WormBaseID:	WBGene00020330	Length:	697	Species:	Caenorhabditis elegans

Alignment Length:	596	Identity:	161/596 - (27%)
Similarity:	249/596 - (41%)	Gaps:	142/596 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TVILDTKYGQV----------RGLQRKTVY--DKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQ 84
            |.|.....||:          :||.|..:|  |.:....|.|:|||:||:|:|||:.|.....|.
Worm     9 TFIFSWANGQLLEKSRSVWVEQGLVRGNIYNIDGKHIQIFRGVPYAEPPIGELRFKPPVKKTRWH 73

  Fly    85 GVLNCTT------------NRSKPMQRNMLLGIVEGSEDCLHLNVY--VKALKSEKPLPVIVWIY 135
            ..|....            ...|..:.||    ...|||||:|||:  .......|..|::|||:
Worm    74 QELPAVEYGPPCLQFMDFHKNDKFAKTNM----DRQSEDCLYLNVFSPYDTDDESKTYPILVWIH 134

  Fly   136 GGGFQKGEASRDIYSPDY------FMKKPVVFVAINYRLAALGFLSLKD-PKLDVPGNAGLKDQV 193
            ||.|..|.|...|   |.      .:.|.:.||:|||||..|||::.:: .||:  ||.|:.|.|
Worm   135 GGSFLAGSADTGI---DMEVIAANIVSKGIAFVSINYRLGPLGFMNYQNGDKLE--GNFGIWDMV 194

  Fly   194 MALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEW------ 252
            |||:||..||..|||||..:|:||||||.|:..::..:.:|.||.|:||:.||.:::.|
Worm   195 MALQWIQSNIKQFNGDPTKVTVMGESAGGAASSLLALSPKTSGLLHQAIIMSGSSMAGWAIHRHS 259

  Fly   253 --VESPDNNWAFRLAQNLGYKGDEKD--ADVLSFL------SKVCARQ---IAAIDQDVINLDE- 303
              ..|.||..|:...:....:.|.|:  .|....|      |.:|..|   |..:..|:..:|:
Worm   260 QPAYSVDNLVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVKINCLTDDMTQMDKM 324

  Fly   304 --VRSFLLFAFGPV----------IEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFS 356
              :|..|.|: .|:          :.....|..:||.....|:..  ...||::.|
Worm   325 NCLRKELNFS-SPLFRKALAAELGVSKMVVDGDLVPSSGVSLVRN--NARIPIMTG--------- 377

  Fly   357 YQLVRKDPWALKN--FHNILPREVRETSSLEGQ--------------DLLVRRLKQLYFNNEMQE 405
              :.||: |..|.  |:|:..|:..:.|.:|.|              :.|.....||..|..:..
Worm   378 --VARKE-WGHKKAMFYNMHQRDGLKRSDVEEQVYRIIDNSFHETASEKLANSTVQLIANATIVR 439

  Fly   406 SMEM----FEALNIFSHRQIWHDTHRFILARQ----SYAPK-TPTYLYRFDF--DSPHFNQFRRL 459
            .:|.    |.|..:....|.......|:...:    :|..| .|.|||.||:  .||.....|::
Worm   440 YLETPNNEFIADQVVGALQKLESDIEFVAPCEREVAAYVDKGVPVYLYSFDYVPKSPILESERKI 504

  Fly   460 --VCGDR-----------------IRGVAHADELSYLFYNIIASKLDKS--SMEYKTIERMV-GM 502
              :.|.:                 ..|:.||    ::|....:|..:.|  :...:|:.::: .|
Worm   505 YSLFGTKPVEMKRTEKSEILEKAAFHGLDHA----FIFSKGYSSNFEISPYTKREETMSKILCTM 565

  Fly   503 WTSFASSGNPN 513
            .|:|..:|:|:
Worm   566 LTNFVKNGDPS 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	161/596 (27%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	48/112 (43%)
cest-16	NP_741812.2	Abhydrolase	25..608	CDD:389770	157/580 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810