Protein Alignment alpha-Est2 and cest-1.1

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_506506.1
• Gene: cest-1.1 / 179915
• WormBaseID: WBGene00011362
• Length: 673
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 154/596 - (25%)
• Similarity: 259/596 - (43%)
• Gaps: 132/596 - (22%)

  Fly    22 VQQY-----RLSTGHTV---ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQ 78
            :|.|     :||:| |:   ||:..|..: |.|..||        |.|||:.:||:||||:|.|:
 Worm    11 IQMYVCKRVQLSSG-TIEGKILNISYSPL-GNQSATV--------FLGIPFVEPPIGDLRYRKPR 65

  Fly    79 PPEPWQGVL-------NCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSE-KPLPVIVWIY 135
            ||:.|:|||       .|.:|.:| ..:|...|.:  |||||:|||.......| |...|::.::
 Worm    66 PPKSWEGVLVTNEYKSACMSNATK-TYKNKFGGPI--SEDCLYLNVLTNEYCLENKNCSVMMIVH 127

  Fly   136 GGGFQKGEASRDIYSPDYFMK------KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVM 194
            |||:....||  .::|:..:.      :.:|.|..||||....|......:.|  .|.||.|.:.
 Worm   128 GGGYLTESAS--TFNPEILINNFVGQGRNIVVVTFNYRLGLFSFGQFNGDRGD--KNFGLYDMIE 188

  Fly   195 ALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNN 259
            ::.|:.:.|.:|.|:.|.|||.|.|||::.:....::..|:||.|:.|:.|         :|..|
 Worm   189 SVNWVRREIENFGGNKNRITLAGHSAGASMIVAFTSSPLTKGLVHQQIIMS---------APMTN 244

  Fly   260 WAFR---------------LAQNLGYK--GDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSF 307
            .:.:               |::.:|:.  .:|:..:..|.|.|..|:||  :|..:..|.....|
 Worm   245 MSKKSNFKGMTVMAQMVGCLSEEIGFNKLSEEQVENTYSCLRKKSAQQI--LDAQLWLLQNSTYF 307

  Fly   308 LLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHN 372
            |  ...|:.|.:.||:      .::|.:......|..::|..:.|...|..::  ||       .
 Worm   308 L--GAPPIDEHFLTDY------PENLYASKSIYPINTLIGTTTLEVEESSYII--DP-------A 355

  Fly   373 ILPREVRETSSL---------EGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRF 428
            ...::|....:|         |..:...::.::.|.|.  ..||.:...:..::....:.|:|.
 Worm   356 FADKKVELLENLCDHIGYVLYEEPETFSKKCQKQYMNG--NSSMNLSNEMEFYTPAIDFADSHT- 417

  Fly   429 ILARQSYAPKTPTYLYRFDF--DSPHFNQFRRLVCGDRIRGVAHADELSYLF---YNIIASKLDK 488
                   :..|..:||.:|:  ..|.::::.      .:|...|:::|.|:|   ..|.|.|
 Worm   418 -------SGNTKVFLYSYDYRGAGPAYDRYL------EVRSPHHSEDLIYVFGTHRGIFAPK--- 466

  Fly   489 SSMEYKTIERMV-GMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLE-----MRDL 547
               :| .||::. ||:..|.:..|| .|. |..||.. ..|||  .:.|.|:.|..     |||.
 Worm   467 ---DY-IIEKIYSGMFADFVNFENP-LPS-GDQKWNQ-YTKEN--REHFLINFDKNFITPGMRDN 522

  Fly   548 PESDCLAVWDT 558
            ..::....|.|
 Worm   523 YYTEAYEFWST 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	137/539 (25%)
		Aes	<117..>221	CDD:223730	32/110 (29%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	150/584 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740