Protein Alignment alpha-Est2 and cest-1.2

DIOPT Version :10

• Sequence 1: NP_524268.3
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 542
• Identity: 147/542 - (27%)
• Similarity: 235/542 - (43%)
• Gaps: 114/542 - (21%)

  Fly    24 QYRLSTGHTVILDTKYGQVRGLQRKTVYD---KEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQG 85
            |:.:||  .|.|.|  |.:.|.|..:.|.   .:...||.||||.:||:||||||.|:|.:.|.|
 Worm    14 QFAIST--KVQLST--GIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSG 74

  Fly    86 VLN-------CTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKALKSE-KPLPVIVWIYGGGFQKG 142
            ||.       |.:|.:|..:...:.|.:  |||||:|||.......| |...|::.::|||:...
 Worm    75 VLETKKFKPACMSNSTKTYKNGGIGGPI--SEDCLYLNVLTNQYCLENKNCSVVIIVHGGGYLFE 137

  Fly   143 EA---SRDIYSPDYF-MKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNI 203
            .|   :.:|...::. ..:.:|.|.|||||...||..|...:.|  .|.|:.|.:.|::|:.:.|
 Worm   138 SAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGFGHLNGFEGD--KNVGIFDTLEAVKWVRREI 200

  Fly   204 AHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSG--------------CALSEWVE 254
            ..|.|:.:.|||.|.|||:..|.....:..|:||.|:.|:.||              .|::|.|.
 Worm   201 KQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGPMTNMSKKSNFKGMTAMAERVG 265

  Fly   255 SPDNNWAFRLAQNLGYKGDEKDAD-VLSFLSKVCARQIAAIDQDVINLDEVRSFLL----FAFG- 313
            .....:.|.       |..|.:.: |.|.|.|..|:::.          :.:.:||    |.||
 Worm   266 CHSKKYGFN-------KLPEHEVEQVYSCLRKKPAQELL----------DAQLWLLQNSTFYFGA 313

  Fly   314 -PVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFE----GLFS---YQLVRKDPWALKNF 370
             ||...:.||:      ..:|.||.....|..::|..:.|    |..|   |.........|||.
 Worm   314 PPVDGEFITDY------PDNLYSEKSIFSINTLLGTTTRELQDTGYISNSNYSKFETKETFLKNL 372

  Fly   371 HNILPREVRETSSLEGQDLLVRRLKQLYFN----NEMQESMEMF-EALNIFSHRQIWHDTHRFIL 430
            .:.:..|:.:    |.:| ...:.::.|.|    ..:.:.||.: :|:|:       .|.|
 Worm   373 CDQIGIEIYK----ESED-FSSKCQKWYINGSDSKSLSDDMEFYTQAINL-------ADAH---- 421

  Fly   431 ARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLF---YNIIASKLDKSSME 492
            ||:  ..|...|.|.:....|.|.::.      :::...|:::|.|.|   ..:.|.|      :
 Worm   422 ARK--GKKVYMYSYAYSGAGPAFKKYM------KVKSPHHSEDLIYTFGTHRGVFAPK------D 472

  Fly   493 YKTIERMV-GMWTSFASSGNPN 513
            | .||.:. ||:..|.:..:|:
 Worm   473 Y-VIEYIYSGMFADFINFEDPS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_524268.3	COesterase	34..556	CDD:395084	143/532 (27%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	146/538 (27%)