DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and cest-35.2

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504398.1	Gene:	cest-35.2 / 178910	WormBaseID:	WBGene00016863	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	159/553 - (28%)
Similarity:	234/553 - (42%)	Gaps:	87/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HTVILDTKYGQVRGLQRKTVYDKEPYF--AFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNR 93
            :|.:.:...|.:||    .||:.....  .:.|||:||.|:|||||:.....|.|...|:| ...
Worm    13 NTEVFNASCGPIRG----NVYEHGDKIVNGYLGIPFAKAPIGDLRFKKSVEAEKWTQPLDC-YKY 72

  Fly    94 SKPMQRNMLLGIVEGS---------EDCLHLNVYVKALKS-EKP--LPVIVWIYGGGFQKGEASR 146
            .....::..||.:..|         ::||:|||:....|| |.|  .||:|:.|||||:.|.:|.
Worm    73 GPGCPQSAALGALMVSQATNHDFAEDNCLNLNVFAPKWKSAEFPNGFPVMVYFYGGGFEVGFSSM 137

  Fly   147 -DIYS-PDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVP-GNAGLKDQVMALRWISQNIAHFNG 208
             |.|| ......|.|:.|..|||:..|||.:..|   ||. ||.||.||.:||:|:.::|..|.|
Worm   138 FDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGD---DVARGNWGLWDQALALQWVQKHIKSFGG 199

  Fly   209 DPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEW-VESPD-NNWAFR-LAQNLGY 270
            ||:|:|:.|.|||.|||..:..:......|.|.|..||.|...: :.|.| ....|| .|.:.||
Worm   200 DPSNVTISGTSAGGASVDFLSLSPHANKYFQKFIPMSGAATCPFGIRSKDVEGLIFREFANHHGY 264

  Fly   271 KGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFL-----------LFAFGPVIEPYETDHC 324
            .|::         ||...:...:.|.::        ||           :|:|.|     ..|..
Worm   265 TGND---------SKSLLQWYQSQDSEI--------FLKAEGYKCPASGMFSFVP-----NFDGD 307

  Fly   325 VVPKRHKDLLSEAWGNDIPVIVGGNSFEGL--FSYQLVRKDPWALKNFHNILPREVRETSSLEGQ 387
            ..||...:|..||  ..:..||....:|||  ..:...:|.|..:.: ..:.|..||      .:
Worm   308 FFPKPFDELRKEA--PKLGAIVSIGEYEGLGFEDFYAGQKTPQQMLS-AALGPEVVR------NR 363

  Fly   388 DLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFDFDSPH 452
            :.:|:|..:.|..|...|:.|......:......:.....|...|.........|||.|::
Worm   364 EEVVKRAAESYLKNGGNENEENIAKTLVEIFGDYYFSVGAFDTVRSLVKYGNTVYLYSFNY---- 424

  Fly   453 FNQFRRLVCGDR--IRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMW-TSFASSGNPNC 514
            ||....:|.|..  .....|..:|.|:|    .....:.|.|.:.:..|:|.: |:||..||||.
Worm   425 FNPNTPIVFGKNRPFNAANHGSDLRYIF----GEGTGEFSKEDRQVMDMMGTYHTNFAKYGNPNG 485

  Fly   515 PELGSAKWEAVQLKENAVEKCFNISH-DLEMRD 546
            ..: |..||...|....  :.|.|.: ..||.|
Worm   486 KGV-SVPWEKYSLDNPG--RYFKIDYPKCEMAD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	151/526 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	48/109 (44%)
cest-35.2	NP_504398.1	COesterase	14..515	CDD:278561	158/550 (29%)
cest-35.2	NP_504398.1	Aes	<105..>239	CDD:223730	58/136 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650