Protein Alignment alpha-Est2 and cest-5.2

DIOPT Version :10

• Sequence 1: NP_524268.3
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 581
• Identity: 130/581 - (22%)
• Similarity: 208/581 - (35%)
• Gaps: 186/581 - (32%)

  Fly    34 ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN-------CTT 91
            |:.|..|::.|.|      ...|..|..||:||||:|.|||:.|:..|.|.||.|       |.:
 Worm    23 IIKTSLGRLEGKQ------SGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPACMS 81

  Fly    92 NRSKPMQRNMLLGIVEGSEDCLHLNVYV--KALKSEKPLPVIVWIYGGG--FQKGEASRDIYSPD 152
            |.:........:     .|||||:|::.  |.||| |...|:|:|:||.  |.......|.:..:
 Worm    82 NSTWTQSPQKWV-----DEDCLHVNIFTSDKCLKS-KDCAVVVYIHGGEIVFDSAVMFNDTFLLE 140

  Fly   153 YFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMG 217
            .|:|:.|:.|...:||......::.|..: .|.|..|.|.::|..::...|.:|.||...|||.|
 Worm   141 SFVKQDVILVIPAFRLGIFSHFTVHDQNI-APNNLALYDIILAQEFVKSEIHNFGGDIQKITLFG 204

  Fly   218 ESAGSASVHVMMTT---EQTRGLFHKAIMQSG----CALSEWVESPDNNWAFRLAQNLG------ 269
            .|.|.....:|..:   .|...||.:.|:.|.    ..|.|.:|..|     |:.::.|
 Worm   205 HSYGGTIASMMAFSSEINQDLSLFQRIIVMSANQYFDTLEEQIERSD-----RVVKHAGCSVPTN 264

  Fly   270 ----YKGDEKDADVLSFLSKVCARQIAAIDQ--------DVINLDEVRSFLLFAFGPVIEPYETD 322
                ....:|:..::..|.|:...::.::.:        |:.||  |....||.....:|..|:
 Worm   265 LARKMNRSQKEKYMMKCLQKLSGMELLSVQRSLEEAGYPDIGNL--VLRGPLFPDVTSLEMLES- 326

  Fly   323 HCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQ 387
                ||.            ||::.|...||.                               :.:
 Worm   327 ----PKM------------IPMLAGCTKFES-------------------------------DDE 344

  Fly   388 DLLVRRLKQLYFNNE---MQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKT---------- 439
            |       :.:|..:   ::..:|..|     .:|:   |....|..||:::.||
 Worm   345 D-------ETHFIGKHFGLENPIECDE-----KYRK---DLENGIFDRQNHSDKTQAIMVPTKLR 394

  Fly   440 ---------PTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKT 495
                     |.|||.|.:....|                |.|:|.|:. .|...:.|::....:.
 Worm   395 VDQLRKHGVPAYLYEFTYPKHAF----------------HTDDLYYIM-GIHPFEKDENEEHLEK 442

  Fly   496 IERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESDCLAVW 556
            :.|  .|..:|...|.|.   :|                       .||.||.||....::
 Worm   443 VYR--NMLINFIKFGEPG---MG-----------------------FEMSDLNESTYFEIY 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_524268.3	COesterase	34..556	CDD:395084	130/579 (22%)
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	130/581 (22%)