Protein Alignment alpha-Est2 and cest-25

DIOPT Version :10

• Sequence 1: NP_524268.3
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 551
• Identity: 169/551 - (30%)
• Similarity: 261/551 - (47%)
• Gaps: 75/551 - (13%)

  Fly    13 MGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYF-AFEGIPYAKPPVGDLRFRA 76
            ||..:..|....|..|  ..|:  |.||.:.|  |:.:::.|... ||:|||||.||:|:|||..
 Worm     1 MGGTVSKHTTPHYPPS--RQVL--TSYGPIEG--RRLIHEGEKQVDAFQGIPYAAPPIGNLRFAL 59

  Fly    77 PQPPEPWQGVLNCTTNRSKPMQRNMLLG--IVEGSEDCLHLNVY--VKALKSEKPLPVIVWIYGG 137
            |||.|.|..|....:..::.:|::.:|.  ....|||.|.||::  |...|:|...|||::|:||
 Worm    60 PQPHEKWTEVRETKSFGARGIQKDHVLSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGG 124

  Fly   138 GFQKGEASR--DIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWIS 200
            ||....|.:  |:....:.:.|.||.|.|.|||..|||.:..|.  .:|.|..|.|.|.||:|:.
 Worm   125 GFVSDSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFWTTGDS--SIPDNVALHDMVFALKWVK 187

  Fly   201 QNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESP-DNNWAFRL 264
            :||..||||||||||||:|||.|||..:..:..:|.||.|.|...|.|...|...| ..|.....
 Worm   188 ENIGLFNGDPNNITLMGQSAGGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNR 252

  Fly   265 AQNLGYKGDEKDADVLSFLSKVCARQIA-AIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPK 328
            ||.:|........|.:..|.::.|.:.| |::.:.::.......|:   ||     :.|:..:|:
 Worm   253 AQEIGVFDGMNTLDWVEKLRELPADKFASALNMEAVDTKTDPELLI---GP-----KYDNLFIPR 309

  Fly   329 RHKDLLSEAWGNDIPVIVGGNSFEGL-FSY---------QLVRKDPWALKNFHNILPREVRETSS 383
            ...:|..||...  |.::|....||| |::         ..|::|..|:.: ..:.|.:.|:.
 Worm   310 PVMELRKEAPMK--PRLLGCAKSEGLVFAFFGLNTKHPLHAVQQDVSAILS-EKLFPLKARDY-- 369

  Fly   384 LEGQDLLVRRLKQL---YFNNEMQESMEMFEA---LNIFSHRQIWHDTHRFILARQSYAPKTPTY 442
               |:..:.:|.::   :...|.|.:|...:.   ||:...:.:..     :|..|   |.||.|
 Worm   370 ---QEKALEKLIEIGTDHSKEEWQRAMVDLKGDSFLNVGIQQNVLD-----VLETQ---PSTPIY 423

  Fly   443 LYRFDFDSPHFNQFRRLVCGDRI--RGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTS 505
            :|.||:.:|....    :.|.::  :...|..::||:..|.|.:..|.:..:||.||....:||:
 Worm   424 MYSFDYCNPKAYG----IMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYKMIEITTRLWTN 484

  Fly   506 FASSGNPNCPELGSA--------KWEAVQLK 528
            ||..||||    |..        |||...::
 Worm   485 FAKYGNPN----GEGDDVAHLEEKWEPATIE 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_524268.3	COesterase	34..556	CDD:395084	163/530 (31%)
cest-25	NP_497609.1	COesterase	15..536	CDD:395084	165/537 (31%)