DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est2 and cest-27

DIOPT Version :9

Sequence 1:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	167/558 - (29%)
Similarity:	255/558 - (45%)	Gaps:	72/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSTGH--TVILDTKYGQVRGLQRKTVYDKEP---YFAFEGIPYAKPPVGDLRFRAPQPPEPWQGV 86
            ||..|  |.:.|...|.::|:.    |::|.   ...|.|||||:||:|.|||:.|.....|...
Worm    18 LSKHHHLTAVHDATCGPIKGVG----YEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEP 78

  Fly    87 LNCTTNRSKPMQRNMLLG-----IVEGSEDCLHLNVYVKALKS-EKP--LPVIVWIYGGGFQKGE 143
            |:|.....:..|.:.|||     :.:..|.||.|||:....:| |.|  .||:|:|:||||....
Worm    79 LDCVRFGPRSPQNDELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAVHS 143

  Fly   144 AS--------RDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWIS 200
            :|        |::.:.|      ||.|.|||||..|||.:..|..  ..||.||.||..||.|:.
Worm   144 SSNYGCASIARNLCTKD------VVVVTINYRLGVLGFFTTGDEV--CRGNLGLWDQTAALEWVQ 200

  Fly   201 QNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSG---CALSEWVESPDNNWAF 262
            :||..|.|||:|:|:.|:|||.|||.::..:..:||||::||..:|   |..:..........:.
Worm   201 ENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSR 265

  Fly   263 RLAQNLGYKGDEKDA-DVLSFLSKVCARQIAAIDQDVI-----NLDEVRSFLLFAFGPVIEPYET 321
            ..|:.||::||:.|: |:|.|           |||..:     .::..|.|.....|.:......
Worm   266 EFARYLGWEGDDNDSEDLLQF-----------IDQQPLYKIEMGINPKRGFKHSQAGSLYFVPNF 319

  Fly   322 DHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQL--VRKDPWALKNFHNILPREVRETSSL 384
            |....||....|..||  ..:.::.|...:||||...|  :.|:|..:|.|   :.|..:|....
Worm   320 DGDFFPKPLNQLRKEA--PKMQIMTGTTKYEGLFFIALGALSKNPEGIKKF---MGRIFKECDYG 379

  Fly   385 EGQDLLVRRLKQLYFNNEMQESME--MFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLYRFD 447
            |..|.:::.:...||.....:..|  |.:.:.......|.:.|:|  ||......:...|.|:||
Worm   380 ERADDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGDYSINYGTYR--LANIMTDLQHDVYFYQFD 442

  Fly   448 F-DSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIERMVGMWTSFASSGN 511
            : :|..|..||.|:   ...|..|..|:.|:....|.||...:..:.|.:..|...:|:||..||
Worm   443 YHNSAGFGVFRWLL---PFLGSTHCTEMRYVLGKGIISKFRPNDNDKKMLHVMTTYFTNFAKYGN 504

  Fly   512 PNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPE 549
            ||.....:.:|:    |.::.....:...||:..::.|
Worm   505 PNGENQETGEWQ----KHDSAHPFRHFKIDLDDSEMVE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	159/523 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	46/114 (40%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	163/547 (30%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	65/176 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16997
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780