Protein Alignment alpha-Est2 and Nlgn3

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_599163.2
• Gene: Nlgn3 / 171297
• RGDID: 621119
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 185/674 - (27%)
• Similarity: 279/674 - (41%)
• Gaps: 179/674 - (26%)

  Fly     1 MEVQVGWPKLIKMGAQLVGHKV--------QQYRLST-GHTVILDTKYGQVRGLQRKTVYDKE-- 54
            |.:|:|.|.|.......||..:        ...|.|| .....::|.:|::||  .:.....|
  Rat     1 MWLQLGLPSLSLSPTPTVGRSLCLILWFLSLVLRASTQAPAPTVNTHFGKLRG--ARVPLPSEIL 63

  Fly    55 -PYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN-------CTTNRSKPMQRNML-------LG 104
             |...:.|:|||.||:|:.||..|:||..|.|:.|       |..|....:...||       |.
  Rat    64 GPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLD 128

  Fly   105 IV-----EGSEDCLHLNVY-----VKALKSE---KP----------------------------- 127
            ||     |.:||||:||||     ||.:..|   ||
  Rat   129 IVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDED 193

  Fly   128 ------LPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGN 186
                  .||:|:|:||.:.:|..:. |..........|:.:.:|||:..|||||..|..  ..||
  Rat   194 IRDSGAKPVMVYIHGGSYMEGTGNM-IDGSVLASYGNVIVITLNYRVGVLGFLSTGDQA--AKGN 255

  Fly   187 AGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSE 251
            .||.||:.||||:|:|||.|.|||..||:.|...|::.|.::..:..:.|||.:||:|||.|||.
  Rat   256 YGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSS 320

  Fly   252 W-VESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKV-CARQIAA---IDQDVINLDEVRSFLLFA 311
            | |......:...||..:|       .:||..:..| |.||.:|   ::||:   ...|..:  |
  Rat   321 WAVNYQPVKYTSLLADKVG-------CNVLDTVDMVDCLRQKSAKELVEQDI---QPARYHV--A 373

  Fly   312 FGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGL-FSYQLVRKDP----------W 365
            |||||     |..|:|...:.|:.:....:..:::|.|..||| |...:|  ||          :
  Rat   374 FGPVI-----DGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVV--DPEDGVSGTDFDY 431

  Fly   366 ALKNFHNIL---PREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFE--ALNIFSHRQ----- 420
            ::.||.:.|   |         ||:|.|...:|.:|.:...:::.|...  .:.:|:..|
  Rat   432 SVSNFVDNLYGYP---------EGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPS 487

  Fly   421 -IWHDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCGDRIRGVAHADELSYLF------ 478
             :..|.|    ||..    :|||.|.|   ..|.....:....|    .||.||:.|:|
  Rat   488 VVTADLH----ARYG----SPTYFYAF---YHHCQSLMKPAWSD----AAHGDEVPYVFGVPMVG 537

  Fly   479 -YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDL 542
             .::......|:.:....:  ::..||:||.:|:||.|.....|:  :..|.|..|:
  Rat   538 PTDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNKPVPQDTKF--IHTKANRFEE-------- 590

  Fly   543 EMRDLPESDCLAVWDTFYPRESLF 566
                       ..|..:.||:.|:
  Rat   591 -----------VAWSKYNPRDQLY 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	168/589 (29%)
		Aes	<117..>221	CDD:223730	46/146 (32%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	175/635 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..195		0/25 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..691

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740