Protein Alignment alpha-Est2 and Ces3b

DIOPT Version :9

• Sequence 1: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 597
• Identity: 170/597 - (28%)
• Similarity: 246/597 - (41%)
• Gaps: 134/597 - (22%)

  Fly    29 TGHTVI---LDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCT 90
            ||..||   :||..|:|||.|............|.|||:|:.|||.|||.||.||:||:||.:.:
Mouse    30 TGPKVIQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDAS 94

  Fly    91 TNRSKPMQR-----NMLLGIVEG------SEDCLHLNVYVKA-LKSEKPLPVIVWIYGGGFQKGE 143
            .|....:|.     |...|:.|.      |||||.||:|... :.:....||:|||:||....|.
Mouse    95 INPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGS 159

  Fly   144 A-SRD-----IYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQN 202
            : |:|     .|.       .||.|.:.|||...||||..|..:  |||.|..|.|.||||:..|
Mouse   160 STSQDGSALAAYG-------DVVVVTVQYRLGIFGFLSTGDKHM--PGNRGFLDVVAALRWVQGN 215

  Fly   203 IAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCA-------LSEWVESPDNNW 260
            ||.|.||||.:|:.|.|||...|..:..:..:.||||:||.|||..       :..|.|:  .|:
Mouse   216 IAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPEA--QNF 278

  Fly   261 AFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCV 325
            |..:|     .|....|:::..|.:...:.:  |.|..:|:.                |..:...
Mouse   279 ANSVA-----CGSASPAELVQCLLQKEGKDL--IKQKNVNIS----------------YIVNDSF 320

  Fly   326 VPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQDLL 390
            .|:|.:.||::.....:|.::|..:.|  |.        |.|....|||.:    ...|..:|||
Mouse   321 FPQRPEKLLADQQFPTVPYLLGVTNHE--FG--------WLLLKSLNILDK----LEHLSREDLL 371

  Fly   391 ----------------VRRLKQLYFNNEMQESMEMF---EALNIFSHRQIWHDTHRFILARQSYA 436
                            :..:...|.:|...:|...:   |.|...|          ||:...:::
Mouse   372 EISRPFLAIMEVPPEIMPTVIDEYLDNGSDQSATRYAFQELLGDIS----------FIIPTLNFS 426

  Fly   437 -----PKTPTYLYRFDFDSPHFNQFR-RLVCGDRIRGVAHADELSYLFYNIIASKLDKSSM---- 491
                 ...|.:||.|......|.:|: ..|..|      ||.|.|::|.....:  |:||:
Mouse   427 KYLRDAGCPVFLYEFQHTPSSFAKFKPAWVKAD------HASENSFVFGGPFLT--DESSLLAFP 483

  Fly   492 ----EYKTIE-RMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLEMRDLPESD 551
                |.|.:. .|:..|:.||.:||||  ..|...|..:    |.:|:...|..:.......:..
Mouse   484 EATEEEKQLSLTMMAQWSQFARTGNPN--GKGLPPWPQL----NQLEQYLEIGLESRTGVKLKKG 542

  Fly   552 CLAVWDTFYPRE 563
            .|..|....||:
Mouse   543 RLQFWTETLPRK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	160/552 (29%)
		Aes	<117..>221	CDD:223730	44/110 (40%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	163/582 (28%)
		Aes	75..>245	CDD:223730	70/178 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740