Protein Alignment alpha-Est2 and Ces1c

DIOPT Version :10

• Sequence 1: NP_524268.3
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 595
• Identity: 185/595 - (31%)
• Similarity: 276/595 - (46%)
• Gaps: 139/595 - (23%)

  Fly    30 GHTV---ILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT 91
            ||::   ::||..|:|.|........::|...|.|:|:||||:|.|||..|||.|||..|.|.|:
Mouse    18 GHSLLPPVVDTTQGKVLGKYISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATS 82

  Fly    92 NRSKPM-----------------QRNML-LGIVEGSEDCLHLNVYVKA-LKSEKPLPVIVWIYGG 137
              ..||                 ::.:| |.|   |||||:||:|..| |.....|||:|||:||
Mouse    83 --YPPMCSQDAGWAKILSDMFSTEKEILPLKI---SEDCLYLNIYSPADLTKSSQLPVMVWIHGG 142

  Fly   138 GFQKGEASRDIYSPDY-----FMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALR 197
            |...|.||      .|     ...:.||.|.|.|||...|..|..|.  ..|||....||:.|||
Mouse   143 GLVIGGAS------PYNGLALSAHENVVVVTIQYRLGIWGLFSTGDE--HSPGNWAHLDQLAALR 199

  Fly   198 WISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAF 262
            |:..|||:|.|:|:::|:.|||:|..||.|::.:...:.|||:||.:||..::
Mouse   200 WVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVIN------------ 252

  Fly   263 RLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYE------T 321
               .|:|.|..:...::::.||:......||:.|.:  ..:..|.||...|.::: |.      .
Mouse   253 ---TNVGKKNIQAVNEIIATLSQCNDTSSAAMVQCL--RQKTESELLEISGKLVQ-YNISLSTMI 311

  Fly   322 DHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILP--REVRETSSL 384
            |..|:||..:::|:|...|.:|.|||.|..|  |.:.:    |..|:   |:||  :...||:|
Mouse   312 DGVVLPKAPEEILAEKSFNTVPYIVGFNKQE--FGWII----PMMLQ---NLLPEGKMNEETAS- 366

  Fly   385 EGQDLLVRRLKQLYFNNEMQESMEMFEA-------------------LNIFSHRQIWHDTHRFIL 430
                ||:||     |::|:..|..|..|                   |::|.  .|:......:|
Mouse   367 ----LLLRR-----FHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFG--DIFFGIPAVLL 420

  Fly   431 ARQSYAPKTPTYLYRFDFDSPHFNQFRR--LVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEY 493
            :|........||:|.|.: .|.|...:|  .|.||      |.||:.::|.   |..|.:.:.|.
Mouse   421 SRSLRDAGVSTYMYEFRY-RPSFVSDKRPQTVEGD------HGDEIFFVFG---APLLKEGASEE 475

  Fly   494 KT-IERMV-GMWTSFASSGNPN------CPE---------LGSAKWEAVQLKENAVEKCFNISHD 541
            :| :.:|| ..|.:||.:||||      .||         :|:...:|.:||  |.|..|  ..:
Mouse   476 ETNLSKMVMKFWANFARNGNPNGEGLPHWPEYDEQEGYLQIGATTQQAQRLK--AEEVAF--WTE 536

  Fly   542 LEMRDLPESD 551
            |..::.||:|
Mouse   537 LLAKNPPETD 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_524268.3	COesterase	34..556	CDD:395084	183/588 (31%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	174/561 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554