Protein Alignment alpha-Est2 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_524268.3
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 615
• Identity: 181/615 - (29%)
• Similarity: 275/615 - (44%)
• Gaps: 138/615 - (22%)

  Fly    34 ILDTKYGQVRGLQRKTVYDKE---PYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT---- 91
            :::|.||:|||::|:  .:.|   |...|.|:|||.||:|..||:.|:.|..|.||.|.||
  Rat    43 VVNTAYGRVRGVRRE--LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPA 105

  Fly    92 ---NRSKPMQRNML------------LGIVEGSEDCLHLNVYVKALKSEKPL------------- 128
               |....:...||            ..:...|||||:||:||..  .:.||
  Rat   106 CPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPT--EDGPLTKKRDEATLNPPD 168

  Fly   129 ---------PVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVA-INYRLAALGFLSLKDPKLDV 183
                     ||:::::||.:.:|  :.:::..........|.|| :||||..|||||..|..  .
  Rat   169 TDIRDSGKKPVMLFLHGGSYMEG--TGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQA--A 229

  Fly   184 PGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCA 248
            .||.||.||:.||||:|:|||||.|||..||:.|..||::.|::::.:..:.|||.|||.|||.|
  Rat   230 KGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTA 294

  Fly   249 LSEW-VESPDNNWAFRLAQNLGYKGDEKDA-DVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFA 311
            :|.| |......:...||..:|.  |.:|: :.:..|.:..:|::  :||||   ...|..:  |
  Rat   295 ISSWSVNYQPLKYTRLLAAKVGC--DREDSTEAVECLRRKSSREL--VDQDV---QPARYHI--A 350

  Fly   312 FGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGL-FSYQLVRKD--------PWAL 367
            ||||:     |..|||...:.|:.:....:..:::|.|..||| |.......:        .:.:
  Rat   351 FGPVV-----DGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTV 410

  Fly   368 KNFHNIL---PREVRETSSLEGQDLLVRRLKQLYF------NNEMQESMEMFEALNIFSHRQIWH 423
            .||.:.|   |         ||:|:|...:|.:|.      |.||:..    ..|.:|:..| |
  Rat   411 SNFVDNLYGYP---------EGKDVLRETIKFMYTDWADRDNGEMRRK----TLLALFTDHQ-W- 460

  Fly   424 DTHRFILARQSYAPKTPTYLYRFDFDSP-HFNQFRRLVCGDRIR----GVAHADELSYLF----- 478
                       .||...|.....|:.|| :|..|.. .|....|    ..||.|||.|:|
  Rat   461 -----------VAPAVATAKLHADYQSPVYFYTFYH-HCQAEGRPEWADAAHGDELPYVFGVPMV 513

  Fly   479 --YNIIASKLDKSSMEYKTIERMVGMWTSFASSGNPNCPELGSAKW---------EAVQLKENAV 532
              .::......|:.:....:  ::..||:||.:|:||.|.....|:         |.|..|.|:.
  Rat   514 GATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSK 576

  Fly   533 EKCF-NISHDLEMRDLPESDCLAVWDTFYP 561
            ||.: :|.....:||...::.:|.|....|
  Rat   577 EKQYLHIGLKPRVRDNYRANKVAFWLELVP 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est2	NP_524268.3	COesterase	34..556	CDD:395084	179/608 (29%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	179/608 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836